105285-08-3

Upstream product

• 699-83-2 2,6-dihydroxylacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 101946-89-8 4,2',6'-tris(methoxymethoxy)chalcone 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 110-87-2 3,4-dihydro-2H-pyran 
• 63854-17-1 2-hydroxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]acetophenone 

Downstream Products

• 64687-96-3 5-hydroxy-2-(4-hydroxphenyl)chroman-4-one 
• 86788-60-5 5,4'-dihydroxyflavanol 
• 854245-26-4 4',5-diacetoxyflavan-4-one 
• 745-39-1 5,4'-diacetoxyflavanone 
• 86788-62-7 (Z)-4-methoxy-2-(4-methoxybenzylidene)benzofuran-3(2H)-one 
• 6665-67-4 5,4'-dihydroxyflavone 
• 105285-09-4 (E)-1-(2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Acid catalyzed stereoselective rearrangement and dimerization of flavenes: synthesis of dependensin

Appropriately substituted flavenes undergo stereoselective rearrangement and dimerization when treated with methanolic hydrochloric acid to give benzopyranobenzopyrans. A rationale for the rearrangement is proposed. This synthetic methodology has been used for a high yield synthesis of the natural product dependensin.

Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase

A series of hydroxy- and hydroxy-methoxychalcones was synthesized and the inhibitory activity and selectivity of the compounds towards bovine lens aldose reductase (AR) were tested. All the compounds display affinity for AR. The most active proved to be 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)propen-1-one (isoliquiritigenin, IC50= 7.60 μM). The selectivity of this compound was also tested, its inhibitory activity being assayed against glutathione reductase and sorbitol dehydrogenase.

HETEROCYCLES. XIX. REACTION OF 2'-HYDROXYCHALCONES WITH ALKALINE HYDROGEN PEROXIDE

Reaction of 2'-hydroxychalcones, which contain the hydroxyl and/or the methoxyl group at the 4- and 6'-positions, with alkaline hydrogen peroxide has been examined.It is observed that these substituents intricately influence the formation of the products.

Synthesis of (+/-)-Fistacacidin

Synthesis of fistacacidin and (+/-)-2,3-trans-5,4'-dimethoxyflavan-3-ol (XVII) are reported.Synthesis of XII, starting from monobenzyl ether of 2,6-dihydroxyacetophenone (I) involves the reacti

Process for treating inflammation

A process for treating inflammation locally or topically by administering a compound of the formula: STR1 wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; NH2, R