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Usage

Uses

Used in Pharmaceutical Industry:
5-METHYL-1,2-BENZISOXAZOLE is used as a building block for the synthesis of various drugs and biologically active molecules, contributing to the development of new therapeutic agents.
Used in Neuroprotective and Antioxidant Research:
5-METHYL-1,2-BENZISOXAZOLE is studied for its potential neuroprotective and antioxidant properties, indicating its possible use in treatments for neurological disorders and conditions related to oxidative stress.
Used in Material Science:
5-METHYL-1,2-BENZISOXAZOLE is investigated for its potential use in the development of novel materials, suggesting its role in creating innovative substances with unique properties.
Used as a Precursor in Heterocyclic Chemistry:
5-METHYL-1,2-BENZISOXAZOLE serves as a precursor in the synthesis of heterocyclic compounds, which are important in various chemical and pharmaceutical applications.

Upstream product

• 1726-86-9 2-hydroxy-5-methylbenzaldehyde oxime 

Downstream Products

• 96182-94-4 4,4'-dimethyl-2,2'-(2-aza-propanediyl)-di-phenol 

Relevant academic research and scientific papers

An efficient synthesis of oxazolines: Via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles

A formal [3 + 2] cycloaddition reaction between the C and O terminals of azaoxyallyl cations formed in situ and 1,2-benzisoxazoles has been realized. This one-pot cycloaddition method provided an effective and practical pathway to synthesize oxazoline in good yields under mild conditions. The title products exhibited unique fluorescence properties.

Rh(II)-Catalyzed Transannulation of N-Sulfonyl-1,2,3-Triazoles with 2,1-Benzisoxazoles or 1,2-Benzisoxazoles

A Rh(II)-catalyzed transannulation of N-sulfonyl-1,2,3-triazoles with 2,1-benzisoxazoles has been developed, which affords an efficient method for the synthesis of quinazoline derivatives. The transformation represents an unprecedented example which utilizes N-sulfonyl-1,2,3-triazole as an aza-[2C]-component in cycloadditions. Meanwhile, a Rh(II)-catalyzed formal [3 + 2] cycloaddition of N-sulfonyl-1,2,3-triazoles with 1,2-benzisoxazoles is also presented, which enables the rapid synthesis of functionalized imidazole derivatives.

[3 + 2]-Cycloaddition of Azaoxyallyl Cations with 1,2-Benzisoxazoles: A Rapid Entry to Oxazolines

A novel and efficient [3 + 2] cycloaddition reaction of azaoxyallyl cations and 1,2-benzisoxazoles to give oxazoline derivatives has been developed. The transformation provides a rapid entry to functionalized oxazoline scaffolds under mild and transition-metal-free conditions, which will greatly expand the reaction types of heterocycle chemistry and pave the way for syntheses of bioactive compounds.