5-METHYL-1,2-BENZISOXAZOLE

Base Information

• Chemical Name: 5-METHYL-1,2-BENZISOXAZOLE
• CAS No.: 10531-77-8
• Molecular Formula: C8H7 N O
• Molecular Weight: 133.15
• Hs Code.: 2934999090
• Mol file: 10531-77-8.mol

Synonyms:5-METHYL-1,2-BENZISOXAZOLE

Chemical Property of 5-METHYL-1,2-BENZISOXAZOLE

Chemical Property:

• PSA: 26.03000
• LogP: 2.13620

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-1,2-BENZISOXAZOLE

There total 1 articles about 5-METHYL-1,2-BENZISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-hydroxy-5-methylbenzaldehyde oxime (1726-86-9) → 5-methylbenzo[d]isoxazole (10531-77-8)

Guidance literature:

With triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 0.0166667h;

DOI:10.1021/acs.orglett.6b02454

Reference yield: 88.0%

1-(4-methylbenzensulfonyl)-4-phenyl-1H-1,2,3-triazole (884866-01-7) + 5-methylbenzo[d]isoxazole (10531-77-8) → 4-methyl-2-(4-phenyl-1-tosyl-1H-imidazol-2-yl)phenol

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In 1,2-dichloro-ethane; for 0.5h; Heating; Sealed tube;

DOI:10.1021/acs.orglett.6b02454

Reference yield: 84.0%

5-methylbenzo[d]isoxazole (10531-77-8) + 3-phenylpropionic acid tert-butyl ester (93139-50-5) → 2-(2-hydroxy-5-methylphenyl)-4-phenyl-6H-1,3-oxazin-6-one

Guidance literature:

With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver(I) triflimide; In 1,2-dichloro-ethane; at 80 ℃; for 28h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02663

upstream raw materials:

2-hydroxy-5-methylbenzaldehyde oxime

Downstream raw materials:

4,4'-dimethyl-2,2'-(2-aza-propanediyl)-di-phenol