1053228-82-2Relevant academic research and scientific papers
In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
Gaspar, Alexandra,Reis, Joana,Matos, Maria Joao,Uriarte, Eugenio,Borges, Fernanda
experimental part, p. 914 - 918 (2012/09/10)
A selected series of chromone carboxamides synthesized in our laboratory were evaluated by radioligand binding studies towards adenosine receptors. All the chromone-3-carboxamides (compounds 8-12) exhibit A2B receptor displacement percentage su
Discovery of novel A3 adenosine receptor ligands based on chromone scaffold
Gaspar, Alexandra,Reis, Joana,Kachler, Sonja,Paoletta, Silvia,Uriarte, Eugenio,Klotz, Karl-Norbert,Moro, Stefano,Borges, Fernanda
experimental part, p. 21 - 29 (2012/07/28)
A project focused on the discovery of new chemical entities (NCEs) as AR ligands that incorporate a benzo-γ-pyrone [(4H)-1-benzopyran-4-one] substructure has been developed. Accordingly, two series of novel chromone carboxamides placed at positions C2 (co
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors
Gaspar, Alexandra,Silva, Tiago,Yá?ez, Matilde,Vina, Dolores,Orallo, Franscisco,Ortuso, Francesco,Uriarte, Eugenio,Alcaro, Stefano,Borges, Fernanda
experimental part, p. 5165 - 5173 (2011/09/16)
Two series of novel chromone derivatives were synthesized and investigated for their ability to inhibit the activity of monoamine oxidase. The SAR data indicate that chromone derivatives with substituents in position 3 of γ-pyrone nucleus act preferably a
CHROMONE DERIVATIVES FOR USE AS ANTIOXIDANTS/PRESERVATIVES
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Page/Page column 7-8, (2008/12/07)
The current invention depicts the synthesis of new chromone amide derivatives placed at positions C2 and C3 of the chromone nucleus. The synthesised compounds possess the general formulas (I) and (II) as displayed below. This new compounds possessing different substitution patterns were obtained through a condensation reaction between 2- or 3 - carboxychromone and aniline (phenylamine) or its substituted derivatives in fairly good yields. The syntheses of the dihydroxylated compounds were performed by a demethylation reaction of the previously obtained monomethoxylated chromones. Some of these compounds possess a putative use as antioxidant/preservatives for pharmaceutical, cosmetic and/or food industries.
