1687-53-2

Basic information

• Product Name: 5-Amino-2-methoxyphenol
• Synonyms: Phenol, 5-amino-2-methoxy-;5-AMINOGUAIACOL;5-AMINO-2-METHOXYPHENOL;3-HYDROXY-4-METHOXYANILINE;2-METHOXY-5-AMINOPHENOL;TIMTEC-BB SBB007884;5-Amino-2-Methoxyphenol 2-Methoxy-5-Aminophenol;5-Amino-2-Methyoxyphenol
• CAS NO: 1687-53-2
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15
• EINECS: 216-873-8
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan
• Mol File: 1687-53-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 130-132 °C(lit.)
• Boiling Point: 255.1°C (rough estimate)
• Flash Point: 130.8 °C
• Appearance: grey-brown to dark brown crystalline powder
• Density: 1.1997 (rough estimate)
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: slightly soluble
• PKA: 10.02±0.10(Predicted)
• Water Solubility: slightly soluble
• BRN: 2717084
• CAS DataBase Reference: 5-Amino-2-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-methoxyphenol(1687-53-2)
• EPA Substance Registry System: 5-Amino-2-methoxyphenol(1687-53-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-20/22
• Safety Statements: 26-36-37/39
• RIDADR: 2811
• WGK Germany: 3
• PackingGroup: II
• Hazardous Substances Data: 1687-53-2(Hazardous Substances Data)

Usage

Chemical Properties

grey-brown to dark brown crystalline powder

General Description

5-Amino-2-methoxyphenol reacts with ninhydrin to yield tetrahydroindeno[1,2-b]indolones.

InChI:InChI=1/C7H9NO2/c1-10-7-3-2-5(8)4-6(7)9/h2-4,9H,8H2,1H3

Upstream product

• 195534-24-8 N-(5-hydroxypentyl)-2-hydroxy-1-methoxy-4-aminobenzene 
• 53606-41-0 2-methoxy-5-nitrophenyl acetate 
• 636-93-1 5-nitroguaiacol 
• 53606-43-2 5-amino-2-methoxyphenyl acetate 

Downstream Products

• 107183-55-1 5-methylcyclohexanone-1,2-dione-1'-(3'-hydroxy-4'-methoxy)phenylhydrazone 
• 195533-52-9 2-Hydroxy-1-methoxy-4-pentafluorophenylsulfonamidobenzene 
• 406728-90-3 N-[Nα-(9-fluorenylmethoxycarbonyl)-Nδ-trityl-L-glutaminyl]-3-hydroxy-4-methoxyaniline 
• 189191-61-5 5-(dimethylamino)-2-methoxyphenol 
• 892413-82-0 5-[[6-[[5-chloro-2-[(6-hydroxyhexyl)oxy]phenyl]amino]-4-pyrimidinyl]amino]-2-methoxy-phenol 
• 892545-89-0 5-(6-chloro-pyrimidin-4-ylamino)-2-methoxy-phenol 
• 170229-80-8 4-methoxy-3-(2-morpholinoethoxy)aniline 
• 777859-78-6 5,7-dichloro-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydroisoindol-1-one 
• 205447-31-0 4-(3-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)quinoline hydrochloride 
• 205448-27-7 5-{[(3-hydroxy-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 154464-26-3 3-(cyclopentyloxy)-4-methoxybenzenamine 
• 855937-48-3 acetic acid-(3-allyloxy-4-methoxy-anilide) 
• 138475-02-2 Toluene-4-sulfonic acid 2-methoxy-5-[(E)-3-(2-nitro-phenyl)-acryloylamino]-phenyl ester 
• 138474-98-3 N-(3-hydroxy-4-methoxyphenyl)-3-(2-nitrophenyl)propenamide 

Relevant articles and documents

Hyperbranched Poly(ester-enamine) from Spontaneous Amino-yne Click Reaction for Stabilization of Gold Nanoparticle Catalysts

Hyperbranched polymers have garnered much attention due to attractive properties and wide applications, such as drug-controlled release, stimuli-responsive nano-objects, photosensitive materials and catalysts. Herein, two types of novel hyperbranched poly(ester-enamine) (hb-PEEa) were designed and synthesized via the spontaneous amino-yne click reaction of A2 monomer (1, 3-bis(4-piperidyl)-propane (A2a) or piperazine (A2b)) and B3 monomer (trimethylolpropanetripropiolate). According to Flory's hypothesis, gelation is an intrinsic problem in an ideal A2+B3 polymerization system. By controlling the polymerization conditions, such as monomer concentration, molar ratio and rate of addition, a non-ideal A2+B3 polymerization system can be established to avoid gelation and to synthesize soluble hb-PEEa. Due to abundant unreacted alkynyl groups in periphery, the hb-PEEa can be further functionalized by different amino compounds or their derivates. The as-prepared amphiphilic PEG-hb-PEEa copolymer can readily self-assemble into micelles in water, which can be used as surfactant to stabilize Au nanoparticles (AuNPs) during reduction of NaBH4 in aqueous solution. As a demonstration, the as-prepared PEG-hb-PEEa-supported AuNPs demonstrate good dispersion in water, solvent stability and remarkable catalytic activity for reduction of nitrobenzene compounds.

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics

Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

NOVEL COMPOUNDS FOR USE IN CANCER

It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures of stereoisomers, wherein X, L,R1, R 2, and R 3 are as defined herein, which are cancer cell differentiation inducing agents. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, in particular by cell differentiation therapy.