1053232-60-2

Upstream product

• 1053232-59-9 (1S,3aR,6aS)-ethyl 2-boc-4-(phenoxycarbonothioyloxy)octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 1227703-21-0 (3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 926276-09-7 (1SR,3aRS,6aSR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid 
• 112626-50-3 (3aR,6aS)-octahydrocyclopenta[c]pyrrole hydrochloride 
• 926276-09-7 hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester 
• 402958-16-1 (1S,3aR,6aS)-ethyl 2-boc-4-oxooctahydrocyclopenta[c]pyrrole-1-carboxylate 
• 103871-46-1 3-Ethoxycarbonylmethyl-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium; bromide 

Downstream Products

• 597569-42-1 (1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid 
• 1147103-42-1 (1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride 

Relevant academic research and scientific papers

Telaprevir intermediate preparation method

The invention discloses a telaprevir intermediate preparation method. A telaprevir intermediate is a formula I compound, and a reaction route is as shown in the specification, wherein R is selected from C1-C4 alkyl groups, R1 is selected from hydrogen, C1-C8 alkyl groups, C1-C8 alkoxy groups, C6-C12 aryl groups, alkyl sulfonyl, C6-C12 aryl sulfonyl groups or substituted C6-C12 aryl sulfonyl groups, and P is an amino protection group. The method has advantages of simplicity in operation, safety, freeness of pollution and special requirements on equipment, low production cost, high yield and the like, is suitable for large-scale production and has a high practical value in realization of telaprevir industrialization.

Process for the preparation of a viral protease inhibitor and its intermediates

Process for the preparation of a viral protease inhibitor and intermediates useful in its preparation.

PROCESS FOR THE PREPARATION OF A VIRAL PROTEASE INHIBITOR AND INTERMEDIATES THEREOF

Process for the preparation of a viral protease inhibitor and intermediates useful in its preparation.

TERTIARY AMINE SUBSTITUTED PEPTIDES USEFUL AS INHIBITORS OF HCV REPLICATION

The present invention provides tertiary amine substituted peptides of Formula (I) useful as inhibitors of HCV replication. The variables R and R1-R12 in Formula I are described herein. The invention also includes methods for preparing such compounds. The present invention further includes pharmaceutical compositions containing tertiary amine substituted peptides and methods for using such compounds, including methods for using the compounds to treat hepatitis C infection.