1053239-66-9

Upstream product

• 928628-29-9 7-[(1R)-2-({2-[(3-{[2-(2-chlorophenyl)ethyl]amino}propyl)thio]ethyl}amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one 
• 86-48-6 1-hydroxy-2-naphthoic acid 
• 13078-80-3 2-(2-chlorophenyl)ethanamine 
• 928628-27-7 tert-butyl [2-(2-chlorophenyl)ethyl]{3-[(2-hydroxyethyl)thio]propyl}carbamate 
• 928628-24-4 tert-butyl [2-(2-chlorophenyl)ethyl]{3-[(2-{[(2R)-2-hydroxy-2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)thio]propyl}carbamate 
• 928628-25-5 tert-butyl allyl[2-(2-chlorophenyl)ethyl]carbamate 
• 928628-28-8 tert-butyl [2-(2-chlorophenyl)ethyl]{3-[(2-oxoethyl)thio]propyl}carbamate 
• 928628-26-6 tert-butyl (2-chlorophenethyl)carbamate 
• 1053240-11-1 N-[2-(2-chlorophenyl)ethyl]acrylamide 
• 1053240-13-3 2-[(3-{[2-(2-chlorophenyl)ethyl] amino}propyl)thio]ethanol 
• 1053240-12-2 [(3-{[2-(2-chlorophenyl)ethyl]amino}-3-oxopropyl)thio]acetic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 22568-07-6 1-chloro-2-[(E)-2-nitrovinyl]benzene 

Relevant academic research and scientific papers

SALTS OF A SELECTIVE BETA-2 ANDRENOCEPTOR AGONIST

A pharmaceutically acceptable salt of 7-[(1R)-2-({2-[(3-{[2-(2-Chlorophenyl)ethyl]amino}propyl)thio]ethyl}amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one provided it is not the ditrifluoroacetate, dihydrobromide or di-acetate salt; and the use of such a compound as a medicament (for example in the treatment of respiratory diseases (such as asthma or COPD).

COMBINATIONS OF BETA-2-ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE

The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is 7-[(1R)-2-({2-[(3-{[2-(2-Chlorophenyl)ethyl]amino}propyl)-thio]ethyl}amino)-1-hydroxyethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase Inducer; an IKK2 inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a muscarinic antagonist which is Aclidinium bromide, Glycopyrrolate, Oxitropium bromide, Pirenzepine, telenzepine or Tiotropium bromide; a p38 inhibitor; a PDE inhibitor; a PPAR gamma agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease