1053256-40-8Relevant academic research and scientific papers
A new route to sequential polypeptides combining solid phase synthesis and solution peptide synthesis
Verhaeghe, Josette,Lacassie, Eric,Bertrand, Marylene,Trudelle, Yves
, p. 461 - 464 (1993)
The cleavage of a resin-bound peptide from an oxime resin using the 2-phenacyloxyphenyl ester of an aminoacid provides a peptide with this aminoacid in C-terminal position. The inactive 2-phenacyloxyphenyl peptide ester thus obtained can then be converted into 2-hydroxyphenyl acts active ester. The polymerization of the repeat unit using this mode of activation gives sequential polypeptides of reasonable molecular weight and of high optical purity.
