A new route to sequential polypeptides combining solid phase synthesis and solution peptide synthesis

Article abstract of DOI:10.1016/0040-4039(93)85102-3

The cleavage of a resin-bound peptide from an oxime resin using the 2-phenacyloxyphenyl ester of an aminoacid provides a peptide with this aminoacid in C-terminal position. The inactive 2-phenacyloxyphenyl peptide ester thus obtained can then be converted into 2-hydroxyphenyl acts active ester. The polymerization of the repeat unit using this mode of activation gives sequential polypeptides of reasonable molecular weight and of high optical purity.