10533-30-9

Basic information

• Product Name: 1H-isoindole, 2,3,3a,4,7,7a-hexahydro-
• Synonyms: 1H-isoindole, 2,3,3a,4,7,7a-hexahydro-;2,3,3a,4,7,7a-hexahydro-1H-isoindole;2,3,3a,4,7,7a-hexahydro-1H-isoindole(SALTDATA: FREE)
• CAS NO: 10533-30-9
• Molecular Formula: C₈H₁₃N
• Molecular Weight: 123.198
• Mol File: 10533-30-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 182.91°C at 760 mmHg
• Flash Point: 61.13°C
• Appearance: /
• Density: 0.948g/cm³
• Vapor Pressure: 0.791mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.15±0.20(Predicted)
• CAS DataBase Reference: 1H-isoindole, 2,3,3a,4,7,7a-hexahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-isoindole, 2,3,3a,4,7,7a-hexahydro-(10533-30-9)
• EPA Substance Registry System: 1H-isoindole, 2,3,3a,4,7,7a-hexahydro-(10533-30-9)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 10533-30-9(Hazardous Substances Data)

Usage

General Description

1H-Isoindole, 2,3,3a,4,7,7a-hexahydro- is a chemical compound with the molecular formula C9H11N. It is a bicyclic heterocycle that contains a six-membered ring fused to a five-membered ring. 1H-Isoindole, 2,3,3a,4,7,7a-hexahydro- is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also a precursor in the production of dyes and pigments. The 1H-Isoindole, 2,3,3a,4,7,7a-hexahydro- compound is commonly used in organic chemistry research and can be produced through various synthetic routes. Its chemical properties make it a versatile and valuable compound in the field of chemical synthesis.

InChI:InChI=1/C8H13N/c1-2-4-8-6-9-5-7(8)3-1/h1-2,7-9H,3-6H2

Upstream product

• 85-40-5 1,2,3,6-tertahydrophthalimide 

Downstream Products

• 1031335-28-0 5-aminohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester 
• 203661-68-1 tert-butyl 5-oxohexahydro-1H-isoindole-2(3H)-carboxylate 
• 1446021-66-4 tert-butyl 5-(methylamino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 
• 203661-67-0 tert-butyl 5-hydroxyhexahydro-1H-isoindole-2(3H)-carboxylate 
• 203663-25-6 t-butyl 5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenteno[c]pyrrole-2-carboxylate 
• 148404-28-8 tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 

Relevant articles and documents

FXR RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR, AND USES THEREOF

The present disclosure disclosed a modulator of FXR receptor and preparation and use thereof, which relates to the technical filed of medicinal chemistry. The present disclosure provides a modulator of FXR receptor having a structural formula I or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, which can combine with FXR receptor (that is NR1H4) and be acted as a FXR agonist or a partial agonist for preventing and treating the disease mediated by FXR, such as chronic intrahepatic or extrahepatic cholestasis, hepatic fibrosis caused by chronic cholestasis or acute intrahepatic cholestasis, chronic hepatitis B, gallstone, hepatic carcinoma, colon cancer or intestinal inflammatory disease, etc. Specifically, for some chemical compounds, their EC50 for FXR agonist activity reach below 100nM, which show an excellent FXR agonist activity and an excellent prospect to provide a new pharmaceutical selection in clinical treatment for the disease mediated by FXR.

Substituted heteroaryl compounds and composition thereof, and applicaitons of compounds and composition

The invention provides substituted heteroaryl compounds and a composition thereof, and applicaitons of the compounds and the composition. The compounds are compounds represented by the formula (I) or the formula (II) or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs of the compounds represented by the formula (I) or the formula (II). The invention also provides the pharmaceutical composition comprising the compounds; the compounds and the pharmaceutical composition can adjust the activity of protein kinase, and are used for prevention, processing, treatment and remission of diseases or disorders mediated by the protein kinase.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides new heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of JAK-mediated diseases. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated diseases.