105337-16-4

Upstream product

• 64-17-5 ethanol 
• 68429-53-8 (2,4-dimethylphenyl)acetonitrile 
• 6331-04-0 2,4-dimethylphenylacetic acid 
• 473-72-3 (1'R,3'R)-2-(3'-acetyl-2',2'-dimethylcyclobutyl)acetic acid 
• 824-55-5 2,4-dimethyl-benzyl chloride 
• 55499-44-0 2,4-dimethylbenzeneboronic acid 
• 105-36-2 ethyl bromoacetate 
• 108-38-3 m-xylene 
• 17879-35-5 cis-pinonic acid 

Downstream Products

• 92655-85-1 diethyl 2-(2,4-dimethylphenyl)malonate 
• 867348-77-4 ethyl 2-(2,4-dimethylphenyl)-3-dimethylaminoacrylate 

Relevant academic research and scientific papers

Reductive removal of phenylseleno groups from α-phenylseleno carbonyl compounds by means of tellurolate anions

α-Phenylseleno carbonyl compounds are reduced to the corresponding selenium free carbonyl compounds by reaction with organic and inorganic tellurolate anions.

Palladium-catalyzed cross-coupling of sterically demanding boronic acids with α-bromocarbonyl compounds

A catalyst system generated in situ from Pd(dba)2 and tri(o-tolyl)phosphine mediates the coupling of arylboronic acids with alkyl α-bromoacetates under formation of arylacetic acid esters at unprecedented low loadings. The new protocol, which involves potassium fluoride as the base and catalytic amounts of benzyltriethylammonium bromideas a phase transfer catalyst, is uniquely effective for the synthesis of sterically demanding arylacetic acid derivatives. (Figure presented)

6-Substituted pyridoindolone derivatives, production and therapeutic use thereof

Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.