1053418-71-5Relevant academic research and scientific papers
Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators
Coburger, Claudius,Wollmann, Joerg,Krug, Martin,Baumert, Christiane,Seifert, Marianne,Molnar, Josef,Lage, Hermann,Hilgeroth, Andreas
experimental part, p. 4983 - 4990 (2010/09/10)
Synthesized series of cage dimeric 1,4-dihydropyridines have been systematically evaluated as MDR modulators in in vitro assays to investigate structure-dependent selectivity properties of inhibiting most cancer-relevant efflux pump proteins. Structure-ac
Novel insight in structure-activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes
Coburger, Claudius,Wollmann, J?rg,Baumert, Christiane,Krug, Martin,Molnár, Josef,Lage, Hermann,Hilgeroth, Andreas
experimental part, p. 5871 - 5874 (2009/10/01)
Novel 3,9-diazatetraasteranes have been synthesized with varied aromatic substitution patterns and evaluated as P-glycoprotein (P-gp) inhibitors. Structure-activity relationships (SAR) are discussed in relation to determined physicochemical properties. Th
