105361-75-9

Basic information

• Product Name: Thiazole, 2-(3-nitrophenyl)-
• CAS NO: 105361-75-9
• Molecular Formula: C9H6N2O2S
• Molecular Weight: 206.225
• Mol File: 105361-75-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Thiazole, 2-(3-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2-(3-nitrophenyl)-(105361-75-9)
• EPA Substance Registry System: Thiazole, 2-(3-nitrophenyl)-(105361-75-9)

Safety Data

• Hazardous Substances Data: 105361-75-9(Hazardous Substances Data)

Upstream product

• 1826-11-5 2-phenylthiazole 
• 3034-53-5 2-bromo-1,3-thiazole 
• 13331-27-6 m-nitrobenzene boronic acid 
• 107-20-0 2-chloroethanal 
• 70102-34-0 3-nitrothiobenzamide 

Downstream Products

• 912818-27-0 3-(5-chloro-thiazol-2-yl)-phenylamine 
• 1186493-12-8 5-benzyl-2-(3-nitropheny)thiazole 
• 912818-26-9 5-chloro-2-(3-nitro-phenyl)-thiazole 
• 184097-39-0 3‐(1,3‐thiazol‐2‐yl)aniline 

Relevant articles and documents

Diarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation

Allosteric modulators have attracted significant interest as an alternate strategy to modulate CB1 receptor signaling for therapeutic benefits that may avoid the adverse effects associated with orthosteric ligands. Here we extended our previous structure-activity relationship studies on the diarylurea-based CB1 negative allosteric modulators (NAMs) by introducing five-membered heterocycles to replace the 5-pyrrolidinylpyridinyl group in PSNCBAM-1 (1), one of the first generation CB1 allosteric modulators. Many of these compounds had comparable potency to 1 in blocking the CB1 agonist CP55,940 stimulated calcium mobilization and [35S]GTP-γ-S binding. Similar to 1, most compounds showed positive cooperativity by increasing [3H]CP55,940 binding, consistent with the positive allosteric modulator (PAM)-antagonist mechanism. Interestingly, these compounds exhibited differences in ability to increase specific binding of [3H]CP55,940 and decrease binding of the antagonist [3H]SR141716. In saturation binding studies, only increases in [3H]CP55,940 Bmax, but not Kd, were observed, suggesting that these compounds stabilize low affinity receptors into a high affinity state. Among the series, the 2-pyrrolyl analogue (13) exhibited greater potency than 1 in the [35S]GTP-γ-S binding assay and significantly enhanced the maximum binding level in the [3H]CP5,5940 binding assay, indicating greater CB1 receptor affinity and/or cooperativity.

Synthesis of 2-Arylbenzothiazole and 2-Arylthiazole Derivatives via a Ru-Catalyzed meta-Selective C-H Nitration Reaction

A Ru-catalyzed meta-selective C-H nitration of 2-arylbenzothiazoles and 2-arylthiazoles has been developed. A wide range of functional groups are tolerated, providing the meta-nitrated products in good to excellent yields using Cu(NO3)2/s

IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.