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Upstream product

• 66-83-1 5-methoxytryptamine hydrochloride 
• 52648-13-2 5-methoxytryptamine-2-carboxylic acid 
• 17952-87-3 6-methoxy-2,3,4,9-tetrahydro-β-carbolin-1-one 
• 151397-84-1 2',3'-O-isopropylidene-N-cyclopropyl-6-chloropurine-5'-uronamide 
• 174727-69-6 2-[1-(2,5-Dimethyl-benzyl)-5-methoxy-1H-indol-3-yl]-ethylamine 

Relevant academic research and scientific papers

N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents

Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.