52648-13-2 Usage
General Description
3-(2-aminoethyl)-5-methoxy-1H-indole-2-carboxylic acid is a chemical compound with the molecular formula C12H14N2O3. It is a derivative of the amino acid tryptophan and belongs to the class of indole carboxylic acids. 3-(2-AMINO-ETHYL)-5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID has potential pharmaceutical applications, particularly in the field of psychiatry and neurology, due to its involvement in serotonin synthesis and activity. It may also have antioxidant and anti-inflammatory properties. 3-(2-aminoethyl)-5-methoxy-1H-indole-2-carboxylic acid is of interest for its potential role in the treatment of depression, anxiety, and other psychiatric disorders, as well as for its potential in the development of novel neuropharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 52648-13-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,6,4 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 52648-13:
(7*5)+(6*2)+(5*6)+(4*4)+(3*8)+(2*1)+(1*3)=122
122 % 10 = 2
So 52648-13-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O3/c1-17-7-2-3-10-9(6-7)8(4-5-13)11(14-10)12(15)16/h2-3,6,14H,4-5,13H2,1H3,(H,15,16)
52648-13-2Relevant articles and documents
N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents
Guengoer, Timur,Malabre, Patrice,Teulon, Jean-Marie,Camborde, Francoise,Meignen, Joelle,et al.
, p. 4307 - 4316 (2007/10/02)
Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.
