1053650-29-5

Basic information

• Product Name: C₃₀H₂₉F₃O₈Si
• Synonyms: C₃₀H₂₉F₃O₈Si
• CAS NO: 1053650-29-5
• Molecular Weight: 602.636
• Mol File: 1053650-29-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₉F₃O₈Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₉F₃O₈Si(1053650-29-5)
• EPA Substance Registry System: C₃₀H₂₉F₃O₈Si(1053650-29-5)

Safety Data

• Hazardous Substances Data: 1053650-29-5(Hazardous Substances Data)

Upstream product

• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 157037-56-4 1,3,5-tri-O-benzoyl-2-oxo-α-D-erythro-pentofuranose 

Downstream Products

• 333996-70-6 3',5'-di-O-benzoyl-4-N-benzoyl-2'-C-β-trifluoromethyl-β-D-cytidine 
• 333996-67-1 1,2,3,5-tetra-O-benzoyl-2-C-β-trifluoromethyl-α-D-ribofuranose 
• 333996-72-8 3',5'-di-O-benzoyl-5-methyl-2'-C-β-trifluoromethyl-β-D-uridine 
• 333996-71-7 3',5'-di-O-benzoyl-2'-C-β-trifluoromethyl-β-D-uridine 
• 333996-69-3 3,5-di-O-benzoyl-2-C-β-trifluoromethyl-α-D-1-ribofuranosyl bromide 

Relevant articles and documents

2′-C-branched ribonucleosides. 2. Synthesis of 2′-C-β-trifluoromethyl pyrimidine ribonucleosides

(matrix presented) The first synthesis of 2′-C-β-trifluoromethyl pyrimidine ribonucleosides is described. 1,2,3,5-Tetra-O-benzoyl-2-C-β-trifluoromethyl-α-D-ribofuranose (3) is prepared from 1,3,5-tri-O-benzoyl-α-D-ribofuranose (1) in three steps and converted to 3,5-di-O-benzoyl-2-C-β-trifluoromethyl-α-D-1-ribofuranosyl bromide (5). The 1-bromo derivative (5) is found to be a powerful reaction intermediate for the synthesis of ribonucleosides. The reaction of silylated pyrimidines with (5) in the presence of HgO/HgBr2 affords exclusively the β-anomers (6-8). Deprotection of (6-8) with ammonia in methanol yields the 2′-C-β -trifluoromethyl nucleosides (9-11).