1053658-70-0

Basic information

• Product Name: ALPHA,OMEGA-BIS-HYDROXY 28(ETHYLENE GLYCOL)
• Synonyms: HO-PEG(28)-OH;ALPHA,OMEGA-BIS-HYDROXY 28(ETHYLENE GLYCOL);PEG-28;OCTACOSAETHYLENE GLYCOL;PEG-28 >=95% (oligomer purity)
• CAS NO: 1053658-70-0
• Molecular Formula: C₅₆H₁₁₄O₂₉
• Molecular Weight: 1251.49
• Mol File: 1053658-70-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 990.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.117±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: ALPHA,OMEGA-BIS-HYDROXY 28(ETHYLENE GLYCOL)(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA,OMEGA-BIS-HYDROXY 28(ETHYLENE GLYCOL)(1053658-70-0)
• EPA Substance Registry System: ALPHA,OMEGA-BIS-HYDROXY 28(ETHYLENE GLYCOL)(1053658-70-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1053658-70-0(Hazardous Substances Data)

Upstream product

• 112-60-7 Tetraethylene glycol 
• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 6790-09-6 dodecaethylene glycol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 351342-08-0 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol 
• 477781-69-4 1-phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate 

Relevant articles and documents

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.

Preparation and characterization of a polyrotaxane consisting of monodisperse poly(ethylene glycol) and α-cyclodextrins

Here we describe the preparation and characterization of a polyrotaxane consisting of monodisperse α,ω-diaminopoly(ethylene glycol) (28 mer) and α-cyclodextrins (α-CDs). The monodisperse α,ω-diaminopoly(ethylene glycol) was prepared by stepwise synthesis starting from tetrakis(ethylene glycol) coupled with preparative gel permeation chromatography. The complex between α-CDs and α,ω-diaminopoly(ethylene glycol) was treated with 2,4-dinitrofluorobenzene, which is large enough to prevent dethreading. The product was characterized by gel permeation chromatography (GPC) and UV-vis, 1H NMR, 13C NMR, and 2D NOESY NMR spectroscopies. The 1H NMR and 13C NMR spectra show that the product consists of α-CDs, poly(ethylene glycol), and 2,4-dinitrophenyl groups. The 2D NOESY NMR spectra show that a poly(ethylene glycol) chain is included in cavities of α-CDs. The number of α-CDs in a polyrotaxane was determined from the UV-vis and 1H NMR spectra and optical rotation. Twelve α-CDs were found to be captured in a monodisperse poly(ethylene glycol) chain.