477781-69-4

Basic information

• Product Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
• Synonyms: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate;Benzyl-PEG4-MS
• CAS NO: 477781-69-4
• Molecular Formula: C₁₆H₂₆O₇S
• Molecular Weight: 362.43844
• Mol File: 477781-69-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate(477781-69-4)
• EPA Substance Registry System: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate(477781-69-4)

Safety Data

• Hazardous Substances Data: 477781-69-4(Hazardous Substances Data)

Usage

Chemical class

methanesulfonates

Derivative

methanesulfonic acid

Carbon chain length

13 carbons

Oxygen atoms

4 at specific positions (2, 5, 8, 11)

Aromatic compound

due to the presence of a phenyl group

Common use

as a reagent in organic synthesis reactions and as a protecting group for alcohol functional groups

Importance

unique structure and reactivity make it valuable in organic chemistry research and synthesis applications.

Upstream product

• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 112-76-5 Stearoyl chloride 
• 477775-73-8 1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol 
• 112-60-7 Tetraethylene glycol 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 951260-37-0 C₃₂H₃₁F₂₇O₈ 
• 477775-73-8 1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol 
• 1616876-40-4 1,2-di-O-octadecyl-3-O-(13-phenyl-3,6,9,12-tetraoxatridecyl)-sn-glycerol 
• 1616876-38-0 1,2-O-isopropylidene-3-O-(13-phenyl-3,6,9,12-tetraoxatridecyl)-sn-glycerol 
• 70802-40-3 stearate-PEG8 oligomer 
• 86770-76-5 2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethanamine 
• 1003598-46-6 C₁₈H₂₇F₃O₅ 
• 1053658-70-0 octacosakis(ethylene glycol) 
• 6790-09-6 dodecaethylene glycol 
• 351342-08-0 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol 
• 499136-63-9 (4R)-2,2-dimethyl-4-(15-phenyl-2,5,8,11,14-pentaoxapentadecyl)-1,3-dioxolane 
• 86770-71-0 ((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene 
• 951260-63-2 C₁₉H₃₃NO₆ 

Relevant articles and documents

A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.

Propargylamine-isothiocyanate reaction: Efficient conjugation chemistry in aqueous media

A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method. This journal is the Partner Organisations 2014.

Ionic strength mediated hydrophobic force switching of CF 3-terminated ethylene glycol self-assembled monolayers (SAMs) on gold

We have synthesised novel oligo(ethylene glycol), CF3-terminated switching self-assembled monolayers, which allow the force experienced by a hydrophobic object to be controlled via the ionic strength of the environment. The Royal Society of Chemistry.