10537-77-6Relevant articles and documents
Selective oxidation of phenols to hydroxybenzaldehydes and benzoquinones with dioxygen catalyzed by polymer-supported copper
Takaki, Ken,Shimasaki, Yohei,Shishido, Tetsuya,Takehira, Katsuomi
, p. 311 - 317 (2002)
Oxidation of 2,6-disubstituted 4-methylphenols with dioxygen by using a CuCl2-poly(4-methyl-4′-vinyl-2,2′-bipyridine) catalyst gave the corresponding 4-hydroxybenzaldehydes in high yields. The activity of the catalyst and the selectivity of the products significantly depended on the reaction conditions and the composition of the catalyst. When the molar ratio of the bipyridine unit of the polymer ligand to Cu was unity, i.e., N/Cu = 2, the best results were obtained. Moreover, the reaction is likely to be promoted by coordination of the products to the catalyst. Similarly, 2,3,6-trimethylphenol and related compounds were converted to p-benzoquinones selectively with a CuCl2-poly(4-vinylpyridine) catalyst. These polymer-supported catalysts were readily recovered and are reusable without noticeable decrease of their activity.
Environmentally friendly and highly efficient Co(OAc)2-catalyzed aerobic oxidation to access 2,6-di-electron-donating group substituted 4-hydroxybenzaldehydes
Jiang, Jian-An,Du, Jia-Lei,Zhang, Zhong-Nan,Zhai, Jiao-Jiao,Ji, Ya-Fei
, p. 1430 - 1440 (2016/09/23)
A highly efficient and green aerobic oxidation has been developed for selectively preparing a series of valuable 2,6-dialkyl-, dialkoxyl-, and alkoxylalkyl-substituted 4-hydroxybenzaldehydes from corresponding 4-cresols in good to excellent yields, using a catalytic system of Co(OAc)24H2O (1.0 mol%)-NaOH (1.0 equiv)-O2(1.0 atm) in aqueous ethylene glycol (EG/H2O = 20/1, v/v) at 50 °C. Furthermore, a plausible mechanism was proposed for the direct oxyfunctionalization of the aromatic methyl group into the aldehyde group.
Aryl-substituted rhodanine derivatives
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, (2008/06/13)
Provided are certain aryl-substituted rhodanine derivatives, treatment methods and pharmaceutical formulations thereof.