105372-81-4

Upstream product

• 137022-91-4 7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one 
• 220034-67-3 N-tosyldiscorhabdin C 
• 32884-23-4 2-benzyloxy-4-methoxybenzaldehyde 
• 220034-72-0 2-Benzyloxy-6-iodo-3-methoxy-phenylamine 
• 161156-09-8 {2-[6-Methoxy-4,7-dioxo-1-(toluene-4-sulfonyl)-4,7-dihydro-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester 
• 100245-10-1 2-Benzyloxy-1-methoxy-3-nitro-benzene 
• 70978-05-1 3-methoxy-2-(benzyloxy)benzenamine 
• 15969-08-1 6-methoxy-2-nitrophenol 
• 138540-75-7 6-Methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole-4,7-dione 
• 134755-33-2 6-methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione 
• 153718-76-4 7-Methoxy-1-<(4-methylphenyl)sulfonyl>-3,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one 
• 134755-32-1 4-(benzyloxy)-6-methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole 
• 134755-22-9 ethyl 4-(benzyloxy)-6-methoxyindole-2-carboxylate 
• 143878-19-7 [2-(4-Hydroxy-6-methoxy-1H-indol-3-yl)-ethyl]-carbamic acid 2-trimethylsilanyl-ethyl ester 

Relevant academic research and scientific papers

A biomimetic approach to the discorhabdin alkaloids: Total syntheses of discorhabdins C and E and dethiadiscorhabdin D

The characteristic spirodienone structure of the discorhabdin alkaloids is readily formed by reaction of the tyramine-substituted indoloquinonimines 26, 35, and 36 with cupric chloride, triethylamine, and oxygen. This cyclization provides a possibly biomimetic route to discorhabdins C and E (41 and 42). The unbrominated spirodienone 40 reacts with hydrogen over Pd/C to give enone 46. Bromination at the α position gives a mixture of bromoenones that undergo smooth conversion to dethiadiscorhabdin D (4) upon treatment with basic alumina.

Synthesis of pyrrolo[4,3,2-de]quinolines from 6,7-dimethoxy-4-methylquinoline. Formal total syntheses of damirones A and B, batzelline C, isobatzelline C, discorhabdin C, and makaluvamines A-D

2-Amino-4-nitrophenol and 2-methoxy-5-nitroaniline were converted into the 5-nitroquinolines 6b and 6d, respectively, and then the latter into nitro-acetal 6f. 6,7-Dimethoxy-4-methylquinoline (6g) was nitrated at C-5 and then the methyl substituent conver

Synthetic studies on tetrahydropyrroloquinoline-containing natural products: Syntheses of discorhabdin C, batzelline C and isobatzelline C

Discorhabdin C (1), batzelline C (2) and isobatzelline C (3), metabolites of marine sources sharing a tetrahydropyrroloquinoline core, have been successfully synthesized, and cytotoxicities of several synthetic intermediates were evaluated.

Total synthesis of discorhabdin C: A general aza spiro dienone formation from O-silylated phenol derivatives using a hypervalent iodine reagent

Hypervalent iodine oxidation of O-silylated phenols bearing various types of aminoquinones at the para position in 2,2,2-trifluoroethanol gave azacarbocyclic spiro dienones in good yields. Using this method, the first total synthesis of discorhabdin C, wh

Synthetic studies on novel sulfur-containing alkaloids, prianosins and discorhabdins: Total synthesis of discorhabdin C

The first total synthesis of discorhabdin C, related to the cytotoxic sulfur-containing alkaloids prianosins and discorhabdins is described. The crucial phenolic oxidation of the appropriate phenol carrying no protective group was achieved by electrochemi