105398-46-7Relevant academic research and scientific papers
Detrifluoroacetylation Reaction of Trifluoromethyl-β-diketones: Facile Method for the Synthesis of Succinimide Derivatives and 1,4-Diketones
Wang, Li-Hua,Zhao, Jing
supporting information, p. 4345 - 4348 (2018/08/31)
Currently, a great deal of research efforts are focused on C–C bond activation for development of novel synthetic methodology. In this paper, a detrifluoroacetylation of trifluoromethyl-β-diketones is described, which allows for the synthesis of succinimides and 1,4-diketones through cascade Michael addition/retro-Claisen reaction and nucleophilic substitution/retro-Claisen reaction. The readily available trifluoromethyl-β-diketones, wide substrate scope, and mild conditions make this method very practical.
Development of a Palladium-Catalyzed Carbonylative Coupling Strategy to 1,4-Diketones
Yin, Hongfei,Nielsen, Dennis U.,Johansen, Mette K.,Lindhardt, Anders T.,Skrydstrup, Troels
, p. 2982 - 2987 (2016/07/06)
We report on a three-component palladium-catalyzed coupling strategy for accessing a wide range of 1,4-diketones, which represent important precursors to heterocycles. Our method relies on a carbonylative Heck reaction employing substituted allylic alcohols, aryl iodides, and carbon monoxide. The reaction conditions are mild and do not require high CO pressure, and a wide functional group tolerance is revealed, providing the desired 1,4-diketones in moderate to good yields. Furthermore, the methodology is adaptable to the selective installment of 13C-carbon isotopes at either one or both of the carbonyl positions.
SYNTHESIS OF UNSYMMETRICAL 1,4-DIKETONES VIA THE MICHAEL-STETTER REACTION
Phillips, Richard B.,Herbert, Sue A.,Robichaud, Albert J.
, p. 411 - 418 (2007/10/02)
The cyanide catalyzed 1,4-Michael addition of aldehydes to α,β-unsaturated ketones has been examined with regard to substituent effects.Adjustment of the donor/acceptor relationship aloows for the synthesis of multisubstituted diaryl 1,4-diketones.
