10540-35-9

Usage

Uses

Used in Organic Synthesis:
3-Bromo-4'-fluorobiphenyl serves as a key building block in organic synthesis, where its unique structure and reactivity contribute to the creation of new compounds with potential applications in various fields.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-Bromo-4'-fluorobiphenyl is utilized as a chemical intermediate, playing a crucial role in the development of novel pharmaceuticals. Its distinct chemical properties allow for the synthesis of new drug candidates with potential therapeutic benefits.
Used as a Chemical Intermediate in Production:
3-Bromo-4'-fluorobiphenyl is employed as a chemical intermediate in the production of various compounds, including those used in the manufacturing of specialty chemicals and materials. Its unique structure makes it an essential component in the synthesis process.
It is important to handle 3-Bromo-4'-fluorobiphenyl with care, as it can be harmful if not used properly. Proper safety measures should be taken to ensure its safe use in research and industrial applications.

Upstream product

• 108-36-1 1,3-dibromobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 497-19-8 sodium carbonate 
• 31433-73-5 N-(3'-bromo-biphenyl-4-yl)-acetamide 
• 108-86-1 bromobenzene 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 337535-49-6 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-ethanol 
• 159020-61-8 (4'-fluoro-[1,1'-biphenyl]-3-yl)boronic acid 

Relevant academic research and scientific papers

Visible-Light-Promoted, Catalyst-Free Gomberg-Bachmann Reaction: Synthesis of Biaryls

Biaryls were synthesized via a novel visible-light-promoted Gomberg-Bachmann reaction that does not require a photosensitizer or any metal reagents. The formation of an electron donor-acceptor complex between aryl diazonium salts and pyridine allows, under visible-light irradiation, the synthesis of biaryls in moderate-to-high yields.

Novel imidazole derivatives, production method thereof and use thereof

The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula: wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.

Insecticidal substituted-2,4-diaminoquinazolines

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 2,4-diaminoquinazoline compound of the formula: STR1 wherein R1, R2, R6, R7, W, X, Y, and Z are as defined herein; methods of using the same; novel 2,4-diaminoquinazolines per se; and intermediates in the preparation thereof.

Phase-Transfer-Catalyzed Gomberg-Bachmann Synthesis of Unsymmetrical Biarenes: A Survey of Catalysts and Substrates

Two problems have hindered the Gomberg-Bachmann (GB) and Pschorr reactions of arenediazonium cations: the instability of the arenediazonium salts and side reactions.Arenediazonium tetrafluoroborate and hexafluorophosphate salts can be prepared in high yield and purity and can be stored safely.Unfortunately, these salts are insoluble in most nonpolar organic solvents.Crown ether complexation or other phase-transfer (pt) catalytic methodology can ameliorate this situation, and reactions conducted by the approaches outlined herein often afforded coupling or cyclization products in high yield and corresponding purity.The use of crown ethers, quarternary 'onium salts, lipophilic carboxylic acid salts, and even the polar cosolvent acetonitrile increase the utility of the ptGB reaction dramatically.Sixty examples of couplings are reported along with an assessment of selectivities.A number of examples are also presented of phase-transfer-type Pschorr cyclizations.In the latter case, the use of potassium superoxide, KO2, is introduced to suppress indazole formation.