105404-87-3

Upstream product

• 105378-77-6 1-<2-(4-Chlorphenylethyl)>-4-phenylpiperidin-4-yl-methanamin 
• 66-99-9 β-naphthaldehyde 
• 25026-34-0 4-chlorophenacetyl chloride 
• 105378-94-7 1-(4-Cyano-4-phenylpiperidin-1-yl)-2-(4-chlorphenyl)-1-ethanon 
• 40481-13-8 4-phenyl-4-cyanopiperidine 

Relevant academic research and scientific papers

Platelet aggregation inhibiting and anticoagulant effects of oligoamines, I: N-(4-piperidinyl)methanamines

In concentrations of some μmol/l, 4-aminomethyl-4-phenylpiperidines suitably aralkylated at position 1 inhibit the platelet aggregation induced by collagen. The most potent compound 10 shows an IC50 of 5.5 · 106 mol/l. The metabolism of arachidonic acid in platelets remains unchanged. At a concentration of 10-4 mol/l 10 also depresses the fibrin formation induced by thromboplastin to 25 percent of normal.