105452-95-7Relevant academic research and scientific papers
Regio- and Enantioselective Ni-Catalyzed Formal Hydroalkylation, Hydrobenzylation, and Hydropropargylation of Acrylamides to α-Tertiary Amides
Shi, Lou,Xing, Ling-Ling,Hu, Wen-Bo,Shu, Wei
supporting information, p. 1599 - 1604 (2020/11/30)
The development of enantioselective alkyl–alkyl cross-couplings with coinstantaneous formation of a stereogenic center without the use of sensitive organometallic species is attractive yet challenging. Herein, we report the intermolecular regio- and enantioselective formal hydrofunctionalizations of acrylamides, forging a stereogenic center α-position to the newly formed Csp3–Csp3 bond for the first time. The use of a newly developed chiral ligand enables the electronically-reversed formal hydrofunctionalizations, including hydroalkylation, hydrobenzylation, and hydropropargylation, offering an efficient way to access diverse enantioenriched amides with a tertiary α-stereogenic carbon center which is facile to racemize. This operationally simple protocol allows for the anti-Markovnikov enantioselective hydroalkylation, and unprecedented hydrobenzylation, hydropropargylation under mild conditions with excellent functional group compatibility, delivering a wide range of amides with excellent levels of enantioselectivity.
Iridium-catalyzed enantioselective hydrogenation of α,β- unsaturated carboxylic acids
Li, Shen,Zhu, Shou-Fei,Zhang, Can-Ming,Song, Song,Zhou, Qi-Lin
supporting information; experimental part, p. 8584 - 8585 (2009/02/03)
A highly efficient iridium-catalyzed hydrogenation of α,β-unsaturated carboxylic acids has been developed by using chiral spiro-phosphino-oxazoline ligands, affording α-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities. Copyright
