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Upstream product

• 153181-25-0 (4R,5S,6S,7R)-hexahydro-5,6-bis(2-methoxyethoxymethoxy)-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one 
• 186040-83-5 (4R-(4α,5α,6β,7β))-3,3'-{[tetrahydro-5,6-bis[(2-methoxyethoxy)methoxy]-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl]bis(methylene)}bis(benzonitrile) 
• 28188-41-2 m-(bromomethyl)benzonitrile 

Relevant academic research and scientific papers

Cyclic urea amides: Hiv-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV

Cyclic urea amides, a novel series of HIV-1 protease (HIV PR) inhibitors, have increased activity against drug-resistant mutants of the HIV PR. The design strategy for these inhibitors is based on the hypotheses that (i) the hydrogen-bonding interactions