1054657-29-2Relevant academic research and scientific papers
Lipid A and related compounds. XXXIII. synthesis and structure-activity relationships of N-acylated L-serine or L-threonine-containing D-glucosamine derivatives as mimics of lipid A disaccharide
Miyajima, Keisuke,Gomi, Noriaki,Ikeda, Kiyoshi,Achiwa, Kazuo
, p. 1089 - 1093 (1997)
Four novel N-acylated L-serine or L-threonine-containing non- phosphorylated D-glucosamine derivatives structurally corresponding to the lipid A disaccharide backbone were synthesized. Compounds 2, 3 and 4 exhibited potent mitogenic activity. Among the threonine-linked lipid A analogs (1-3), serine-linked lipid A analogs (4-6) and homoserine-linked lipid A analogs (7-9), the serine compounds (4,6) showed the most potent mitogenic activity.
