Lipid A and related compounds. XXXIII. synthesis and structure-activity relationships of N-acylated L-serine or L-threonine-containing D-glucosamine derivatives as mimics of lipid A disaccharide

DOI: 10.1248/cpb.45.1089

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1089 - 1093 (1997)

Update date:2022-07-30

Topics:

Authors:

Miyajima, Keisuke

Gomi, Noriaki

Ikeda, Kiyoshi

Achiwa, Kazuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.1089

Four novel N-acylated L-serine or L-threonine-containing non- phosphorylated D-glucosamine derivatives structurally corresponding to the lipid A disaccharide backbone were synthesized. Compounds 2, 3 and 4 exhibited potent mitogenic activity. Among the threonine-linked lipid A analogs (1-3), serine-linked lipid A analogs (4-6) and homoserine-linked lipid A analogs (7-9), the serine compounds (4,6) showed the most potent mitogenic activity.

Full text of DOI:10.1248/cpb.45.1089

NII-Electronic Library Service

Products guided by the article

Product name:(2S,3S)-3-((2R,3R,4R,5S,6R)-4,5-Diacetoxy-6-acetoxymethyl-3-amino-tetrahydro-pyran-2-yloxy)-2-tetradecanoylamino-butyric acid benzyl ester

Cas No:1054657-29-2

R&D Labs maybe for 1054657-29-2

Ceresking Ecology & Technology co.,ltd

Contact:86 22 66218397

Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
LIAONING DMSO CHEMICALS CO.,LTD.

website:http://www.chinadmso.com

Contact:+86-427-6503033

Address:FLOOR 16, BLOCK A, FINANCIAL SQUARE, XINGLONGTAI DISTRICT, PANJIN CITY, LIAONING P.R. CHINA
Hangzhou Taiyan Trading Co., Ltd(expird)

Contact:+86-13777583958

Address:NO.63, Xingyi Street, Xihu District, Hangzhou, Zhejiang, China
shijiazhuang alkay chemicals co..ltd(expird)

Contact:86-311-67692035

Address:2601,juntang building,qiaodong district,shijiazhuang
Nanjing lanbai chemical Co.,Ltd.

Contact:+86-25-85499326

Address:Room 908, 9F Taiyue Building,No.285 Heyan Road

Relevant to this article

Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

Doi:10.1016/j.bmcl.2008.06.036
(2008)
Doi:10.1016/0022-1902(63)80365-6
(1963)
Microbiological Transformations, Part 9. Microbiological Transformations of 1,2,5,6-Tetrahydropyrrolo<3,2,1-i,j>quinolin-4-one and of Derivatives of 1,2,3,5,6,7-Hexahydropyrido<3,2,1-i,j>quinoline with the Fungus Cunninghamella elegans

Doi:10.1016/S0040-4020(01)82092-5
(1986)
Selective and Efficient Synthesis of 3,4-Dihydro-β-carboline Derivatives

Doi:10.1055/s-1985-35506
(1985)
P₄VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines

Doi:10.1007/s13738-016-0887-x
(2016)
Hydride affinities of cumulated, isolated, and conjugated dienes in acetonitrile

Doi:10.1021/jo801536m
(2008)

Article Doi