1054661-07-2

Upstream product

• 195976-27-3 N^α-(fluoren-9-ylmethoxycarbonyl)-O-(2-azido-2-deoxy-3,4-O-isopropylidene-α-D-galactopyranosyl)-L-threonine tert-butyl ester 
• 195976-26-2 (2S,3R)-3-((2S,3R,4R,5R,6R)-3-Azido-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester 
• 120791-77-7 N-(9H-fluoren-9-yl)-methoxycarbonyl-O-(3,4,6-tri-O-acetyl-2-azido-2-desoxy-α-D-galactopyranosyl)-1-threonine tert-butyl ester 
• 195976-28-4 N^α-(fluoren-9-ylmethoxycarbonyl)-O-[O-[3',4',6'-tri-O-benzoyl-2'-deoxy-2'-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyl]-(1'->6)-2-azido-2-deoxy-3,4-O-isopropylidene-α-D-galactopyranosyl)-L-threonine tert-butyl ester 

Downstream Products

• 195976-29-5 N^α-(fluoren-9-ylmethoxycarbonyl)-O-[O-[3',4',6'-tri-O-benzoyl-2'-deoxy-2'-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyl]-(1'->6)-3,4-di-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-L-threonine tert-butyl ester 
• 195976-30-8 N^α-(fluoren-9-ylmethoxycarbonyl)-O-[O-(2'-acetamido-3',4',6'-tri-O-benzoyl-2'-deoxy-2'-β-D-glucopyranosyl)-(1'->6)-2-acetamido-3,4-di-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of glycopeptide sequences of repeating units of the mucins MUC 2 and MUC 3 containing oligosaccharide side-chains with core 1, core 2, core 3, core 4 and core 6 structure

An efficient synthesis of glycosylamino acid building blocks containing core 1, core 2, core 3, core 4 or core 6 mucin core oligosaccharide structures linked O-glycosidically to threonine has been developed. These building blocks 6, 10, 16, 24 and 30 can be used directly for coupling reactions in a glycopeptide synthesis. In a multiple-column solid-phase synthesis, they have been used to prepare different series of glycopeptides. Decapeptide sequences have been synthesized from repeating units of the mucins MUC 2 and MUC 3 in which different threonine residues are each systematically glycosylated with an oligosaccharide of core 1, core 2, core 3, core 4 or core 6 structure. Glycopeptides are substrates for the study of the biosynthesis of the saccharide side-chains of mucins.