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(S)-Tetrahydro-2H-pyran-2-carboxylic acid, also known as THP-2-carboxylic acid, is a chemical compound with a molecular formula C7H12O3. It is a derivative of tetrahydropyran and carboxylic acid, characterized by its unique structure and functional groups. (S)-Tetrahydro-2H-pyran-2-carboxylic acid is recognized for its potential in the pharmaceutical and chemical industries due to its versatile properties and applications.

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  • 105499-32-9 Structure
  • Basic information

    1. Product Name: (S)-Tetrahydro-2H-pyran-2-carboxylic acid
    2. Synonyms: (S)-Tetrahydro-2H-pyran-2-carboxylic acid;(2S)-oxane-2-carboxylic acid;2H-Pyran-2-carboxylic acid, tetrahydro-, (S)-
    3. CAS NO:105499-32-9
    4. Molecular Formula: C6H10O3
    5. Molecular Weight: 130.1418
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 105499-32-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 264.5±33.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.185±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 3.70±0.20(Predicted)
    10. CAS DataBase Reference: (S)-Tetrahydro-2H-pyran-2-carboxylic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: (S)-Tetrahydro-2H-pyran-2-carboxylic acid(105499-32-9)
    12. EPA Substance Registry System: (S)-Tetrahydro-2H-pyran-2-carboxylic acid(105499-32-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 105499-32-9(Hazardous Substances Data)

105499-32-9 Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-Tetrahydro-2H-pyran-2-carboxylic acid is used as a building block for the synthesis of various pharmaceuticals and natural products. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Antifungal and Antibacterial Applications:
(S)-Tetrahydro-2H-pyran-2-carboxylic acid is used as an active ingredient in the development of novel drugs for the treatment of infectious diseases. Its potential antifungal and antibacterial properties make it a promising candidate for combating resistant strains of pathogens.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-Tetrahydro-2H-pyran-2-carboxylic acid is used as a versatile intermediate for the preparation of complex organic molecules. Its reactivity and compatibility with various synthetic routes make it a valuable compound for researchers in organic chemistry.
Used in Medicinal Chemistry Research and Development:
(S)-Tetrahydro-2H-pyran-2-carboxylic acid is utilized in the research and development of new therapeutic agents. Its potential applications in medicinal chemistry have led to further exploration of its properties and mechanisms of action, with the aim of discovering innovative treatments for various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 105499-32-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,4,9 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 105499-32:
(8*1)+(7*0)+(6*5)+(5*4)+(4*9)+(3*9)+(2*3)+(1*2)=129
129 % 10 = 9
So 105499-32-9 is a valid CAS Registry Number.

105499-32-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-oxane-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names (-)-tetrahydro-2H-pyran-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105499-32-9 SDS

105499-32-9Relevant articles and documents

Substituted Pyrrolidines and Methods of Use

-

Paragraph 1518, (2018/04/20)

The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Iridium-catalyzed enantioselective hydrogenation of unsaturated heterocyclic acids

Song, Song,Zhu, Shou-Fei,Pu, Liu-Yang,Zhou, Qi-Lin

supporting information, p. 6072 - 6075 (2013/07/05)

Spiral binding: A highly enantioselective hydrogenation of unsaturated heterocyclic acids has been developed by using chiral iridium/spirophosphino oxazoline catalysts (see scheme; BArF-=tetrakis[3,5- bis(trifluoromethyl)phenyl]borate, Boc=tert-butoxycarbonyl). This reaction provided an efficient method for the preparation of optically active heterocyclic acids with excellent enantioselectivities. Copyright

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