105500-09-2 Usage
Description
8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID, also known as a HETE (Hydroxyeicosatetraenoic acid), is a type of eicosanoid derived from arachidonic acid. It possesses an (8R)-hydroxy group and (5Z)-, (9E)-, (11Z)-, and (14Z)-double bonds, which contribute to its unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID is used as a bioactive compound for its potential therapeutic applications. It may play a role in modulating various biological processes and signaling pathways, making it a promising candidate for the development of new drugs targeting specific diseases.
Used in Research and Development:
In the field of scientific research, 8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID is used as a research tool to study the roles of eicosanoids in cellular processes and their potential as therapeutic targets. Its unique structure allows researchers to investigate the effects of specific modifications on its biological activity and interactions with other molecules.
Used in Diagnostic Applications:
8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID may also be used in the development of diagnostic tools and tests, as its presence or levels in biological samples could potentially indicate certain health conditions or responses to treatments. This could aid in the early detection and monitoring of diseases, as well as the evaluation of therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 105500-09-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,5,0 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105500-09:
(8*1)+(7*0)+(6*5)+(5*5)+(4*0)+(3*0)+(2*0)+(1*9)=72
72 % 10 = 2
So 105500-09-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,14-11-,16-13+/t19-/m0/s1
105500-09-2Relevant articles and documents
Crystal structure of a lipoxygenase in complex with substrate: The arachidonic acid-binding site of 8R-lipoxygenase
Neau, David B.,Bender, Gunes,Boeglin, William E.,Bartlett, Sue G.,Brash, Alan R.,Newcomer, Marcia E.
, p. 31905 - 31913 (2014)
Lipoxygenases (LOX) play critical roles in mammalian biology in the generation of potent lipid mediators of the inflammatory response; consequently, they are targets for the development of isoform-specific inhibitors. The regio- and stereo-specificity of the oxygenation of polyunsaturated fatty acids by the enzymes is understood in terms of the chemistry, but structural observation of the enzyme-substrate interactions is lacking. Although several LOX crystal structures are available, heretofore the rapid oxygenation of bound substrate has precluded capture of the enzyme-substrate complex, leaving a gap between chemical and structural insights. In this report, we describe the 2.0 ? resolution structure of 8R-LOX in complex with arachidonic acid obtained under anaerobic conditions. Subtle rearrangements, primarily in the side chains of three amino acids, allow binding of arachidonic acid in a catalytically competent conformation. Accompanying experimental work supports a model in which both substrate tethering and cavity depth contribute to positioning the appropriate carbon at the catalytic machinery.
