1055029-19-0

Upstream product

• 382139-04-0 (S)-1-[(S)-2-Benzyloxycarbonylamino-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 382139-05-1 (S)-1-[(S)-2-Benzyloxycarbonylamino-3-(3-tert-butoxycarbonyloxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester 

Downstream Products

• 382139-11-9 C₆₀H₈₉N₅O₁₂ 
• 382139-09-5 C₄₃H₅₉IN₄O₁₀ 
• 382139-10-8 C₃₈H₅₁IN₄O₈ 
• 382139-23-3 1-[3-(3-tert-butoxycarbonyloxy-phenyl)-2-(2-{[3-(6-hydroxy-8-iodo-7-methyl-octa-1,3,7-trienyl)-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl]-amino}-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid 
• 382139-08-4 1-[3-(3-tert-butoxycarbonyloxy-phenyl)-2-(2-{[3-(6-hydroxy-8-iodo-7-methyl-octa-1,3,7-trienyl)-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl]-amino}-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester 
• 382138-87-6 (S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-tert-butoxycarbonyloxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester 
• 187148-13-6 (-)-sanglifehrin A 

Relevant academic research and scientific papers

A convergent three-component total synthesis of the powerful immunosuppressant (-)-sanglifehrin A

The potent immunosuppressive agent (-)-sanglifehrin A (5), initially discovered in a soil sample from Malawi, has been synthesized in a highly conver soil gent and stereocontrolled manner. The enantioselective approach relies on initial construction of th

Enantioselective total synthesis of the cyclophilin-binding immunosuppressive agent sanglifehrin A

Crafting of the building blocks 1-3 allows the convergent conjoining of 2-3 in advance of macrolactonization. The subsequent linkup of the eastern sector with 1 by Stille coupling enabled the convenient stereocontrolled assembly of the immunosuppressive a