382139-05-1Relevant articles and documents
A convergent three-component total synthesis of the powerful immunosuppressant (-)-sanglifehrin A
Paquette, Leo A.,Duan, Maosheng,Konetzki, Ingo,Kempmann, Christoph
, p. 4257 - 4270 (2002)
The potent immunosuppressive agent (-)-sanglifehrin A (5), initially discovered in a soil sample from Malawi, has been synthesized in a highly conver soil gent and stereocontrolled manner. The enantioselective approach relies on initial construction of th
Enantioselective total synthesis of the cyclophilin-binding immunosuppressive agent sanglifehrin A
Duan, Maosheng,Paquette, Leo A.
, p. 3632 - 3636 (2007/10/03)
Crafting of the building blocks 1-3 allows the convergent conjoining of 2-3 in advance of macrolactonization. The subsequent linkup of the eastern sector with 1 by Stille coupling enabled the convenient stereocontrolled assembly of the immunosuppressive a