1055030-60-8

Upstream product

• 32677-01-3 L-glutamic acid di-tert-butyl ester hydrochloride 
• 172974-16-2 di-tert-butyl <<(3-fluoro-4-nitrophenyl)oxy>carbonyl>-L-glutamate 

Downstream Products

• 172974-18-4 di-tert-butyl <<<3-fluoro-4-phenyl>oxy>carbonyl>-L-glutamate 
• 172974-15-1 (S)-2-{4-[Bis-(2-methanesulfonyloxy-ethyl)-amino]-3-fluoro-phenoxycarbonylamino}-pentanedioic acid di-tert-butyl ester 
• 172974-12-8 (S)-2-{4-[Bis-(2-iodo-ethyl)-amino]-3-fluoro-phenoxycarbonylamino}-pentanedioic acid di-tert-butyl ester 
• 172974-11-7 (S)-2-{4-[Bis-(2-bromo-ethyl)-amino]-3-fluoro-phenoxycarbonylamino}-pentanedioic acid di-tert-butyl ester 

Relevant academic research and scientific papers

Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

Sixteen novel potential prodrugs derived from phenol or aniline mustards and their 16 corresponding drugs with ring substitution and/or different alkylating functionalities were designed.The 4-bis(2-bromoethyl)-(1a), 4-bis(2-iodoethyl)-(1b), and