1055074-80-0Relevant academic research and scientific papers
4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists
Hudkins, Robert L.,Aimone, Lisa D.,Dandu, Reddeppa Reddy,Dunn, Derek,Gruner, John A.,Huang, Zeqi,Josef, Kurt A.,Lyons, Jacquelyn A.,Mathiasen, Joanne R.,Tao, Ming,Zulli, Allison L.,Raddatz, Rita
, p. 194 - 198 (2012/03/10)
H3R structure-activity relationships for a new class of 4,5-dihydropyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modification of the 4,5-dihydropyridazinone moiety to block in vivo metabolism identified 4,4-dimethyl
Gem-substituted αvβ3 antagonists
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, (2008/06/13)
The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αVβ3and/or the αVβ5integrin.
