10551-32-3

Basic information

• Product Name: 2,5-DIHYDROXY-4'-METHYLBIPHENYL
• Synonyms: 1’-biphenyl]-2,5-diol,4’-methyl-[;Dihydroxymethylbiphenyl;4'-methyl[1,1'-biphenyl]-2,5-diol;2-(4-Methylphenyl)benzene-1,4-diol;2-(p-Tolyl)hydroquinone;(1,1'-Biphenyl)-2,5-diol, 4'-methyl-;2-(4-Methylphenyl)-1,4-benzenediol;Einecs 234-135-3
• CAS NO: 10551-32-3
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 214.25976
• EINECS: 234-135-3
• Mol File: 10551-32-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 125°C
• Boiling Point: 389.6°Cat760mmHg
• Flash Point: 192.7°C
• Appearance: /
• Density: 1.192g/cm³
• CAS DataBase Reference: 2,5-DIHYDROXY-4'-METHYLBIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIHYDROXY-4'-METHYLBIPHENYL(10551-32-3)
• EPA Substance Registry System: 2,5-DIHYDROXY-4'-METHYLBIPHENYL(10551-32-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 10551-32-3(Hazardous Substances Data)

Usage

General Description

2,5-Dihydroxy-4'-methylbiphenyl, also known as 4'-methyl-2,5-dihydroxybiphenyl, is a chemical compound with the molecular formula C13H12O2. It is a type of biphenyl, which is a class of organic compounds consisting of two linked benzene rings. This particular compound has two hydroxyl (OH) groups and a methyl (CH3) group attached to the biphenyl ring structure. It is commonly used in the production of pharmaceuticals, dyes, and other organic products. 2,5-dihydroxy-4'-methylbiphenyl is also known for its antioxidant properties and is being studied for its potential therapeutic applications in various medical treatments. However, it is important to handle this compound with caution, as it may pose health risks if not properly handled and used in controlled conditions.

Upstream product

• 30237-07-1 p-tolyl-[1,4]benzoquinone 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 583-63-1 ortoquinone 
• 106-49-0 p-toluidine 
• 583-69-7 2-bromobenzene-1,4-diol 
• 5720-05-8 4-methylphenylboronic acid 
• 888772-17-6 4-acetoxy-4-(4'-methylphenyl)-2,5-cyclohexadienone 
• 36590-52-0 N-phenyl-p-chlorobenzohydrazonoyl chloride 
• 142835-77-6 O-(4'-Methyl-biphenyl-2-yl)-hydroxylamine 

Downstream Products

• 30237-07-1 p-tolyl-[1,4]benzoquinone 

Relevant articles and documents

Reversible formation of aryloxenium ions from the corresponding quinols under acidic conditions

Quinols, 1, are products of the hydration of O-aryloxenium ions, 2, and N-arylnitrenium ions, 3, and they are being investigated for medical uses. Under acidic conditions (pH 1-3) kinetics and products of Br- trapping demonstrate that 1a, 4-phenyl-4-hydroxy-2,5-cyclohexadienone, and 1b, 4-p-tolyl-4-hydroxy-2,5-cyclohexadienone, generate the corresponding oxenium ions 2a and 2b, respectively, as steady-state intermediates. Formation and trapping of the oxenium ions occurs in competition with the acid catalyzed dienone-phenol rearrangement. Because oxenium ion formation is reversible, the ion can only be detected by trapping with a nucleophile. Br- is an efficient trap under acidic conditions because, unlike N3 -, it is not protonated under those conditions. Attempts to detect the oxenium ions 2a and 2b at pH 4.6 and 7.1 with N3- were unsuccessful indicating that oxenium ion formation only occurs under acidic conditions. The oxenium ion 2c could not be detected under acidic conditions from the quinol 1c, 4-(benzothiazol-2-yl)-4-hydroxy-2,5-cyclohexadienone, by Br- trapping methods, even though this ion can be detected during hydrolysis of the corresponding ester, 4c. Although the benzothiazol-2-yl group is a resonance electron donor that is capable of stabilizing an O-aryloxenium ion, it is also a strong inductive electron withdrawing group that hinders the formation of 2c from 1c by decreasing the extent of protonation of 1c to generate 1cH+ and by destabilizing the transition state for ionization of 1cH+. Generation of an oxenium ion from the corresponding quinol is feasible under acidic conditions as long as the 4-substituent of the quinol is both a resonance and inductive electron donor. Copyright

Acid-catalyzed rearrangement of O-(2-arylphenyl)hydroxylamines to aryldihydroazepinones

Acid-catalyzed rearrangement of O-(2-arylpheynl) hydroxylamines followed by ring enlargement afford 7-aryl-2, 3-dihydro-1H-azepin-2-ones. 2-Amino-2-phenyl-3, 5-cyclohexadienone, an intermediate of the reaction, was trapped as the N-trifluoroacetamide.

Stabilized polyglycol for high temperatures

A composition comprising a poly-alkyleneglycol is stablized against molecular degradation and viscosity loss at elevated temperatures by about 0.1 to about 10% by weight of an arylhydroquinone such as p-acetylphenylhydroquinone.