36590-52-0

Basic information

• Product Name: Benzoyl chloride p-chloro-, phenylhydrazone
• Synonyms: BENZENE CARBOHYDRAZONOYL CHLORIDE, 4-CHLORO-N-PHENYL-
• CAS NO: 36590-52-0
• Molecular Formula: C₁₃H₁₀Cl₂N₂
• Molecular Weight: 0
• Mol File: 36590-52-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 369.16°C at 760 mmHg
• Flash Point: 177.062°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: Benzoyl chloride p-chloro-, phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride p-chloro-, phenylhydrazone(36590-52-0)
• EPA Substance Registry System: Benzoyl chloride p-chloro-, phenylhydrazone(36590-52-0)

Safety Data

• Hazardous Substances Data: 36590-52-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10Cl2N2/c14-11-8-6-10(7-9-11)13(15)17-16-12-4-2-1-3-5-12/h1-9,16H/b17-13-

Upstream product

• 15089-07-3 2-(4-Chlorbenzoyl)-1-phenylhydrazid 
• 122-01-0 4-chloro-benzoyl chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 100-63-0 phenylhydrazine 
• 74-11-3 para-chlorobenzoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 2829-26-7 N-(4-chlorobenzylidene)-N'-phenylhydrazine 

Downstream Products

• 40277-68-7 3-(4-chloro-phenyl)-1-phenyl-(3ar,8bc)-3a,8b-dihydro-1H-benzo[4,5]furo[3,2-c]pyrazole 
• 117600-57-4 3-(4-Chlorphenyl)-1,8a-dihydro-1-phenyl<1,2,4>triazolo<4,3-a>pyridin 
• 128671-04-5 3-(4-Chloro-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyrazine 
• 128671-03-4 2-[(4-Chloro-phenyl)-(phenyl-hydrazono)-methyl]-2H-[1,2,4]triazol-3-ylamine 
• 128901-00-8 3-(4-Chloro-phenyl)-1,4,7-triphenyl-8-thia-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 129624-53-9 (4R,5R)-3-(4-Chloro-phenyl)-1,7-diphenyl-4-p-tolyl-8-oxa-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 129624-55-1 (4R,5R)-3-(4-Chloro-phenyl)-4-(4-methoxy-phenyl)-1,7-diphenyl-8-oxa-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 132703-81-2 N-[1-(4-Chloro-phenyl)-1-[1,2,4]triazol-4-yl-meth-(E)-ylidene]-N'-phenyl-hydrazine 
• 128670-96-2 3-(4-Chloro-phenyl)-6-methyl-1-phenyl-1H-pyrazolo[5,1-c][1,2,4]triazole 
• 143033-08-3 3-(4-Chloro-phenyl)-7,8-dimethoxy-1,9b-diphenyl-1,9b-dihydro-5-thia-1,2,3a-triaza-cyclopenta[a]naphthalene 
• 128587-08-6 2-(p-chlorobenzoyl)(4,5-dimethyl-2H-1,2,3-triazole) phenylhydrazone 
• 128587-07-5 1-(p-chlorobenzoyl)(4,5-dimethyl-1H-1,2,3-triazole) phenylhydrazone 
• 110672-25-8 10-(4-Chloro-phenyl)-8-phenyl-8,9-diaza-tricyclo[5.3.3.0^1,7]tridec-9-en-2-one 
• 31023-85-5 dispirodithietane-4',2''-adamantane> 

Relevant articles and documents

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3-CF3-Pyrazoles from Nitrilimines and Isoxazolidinediones

1,4-Diaryl-5-carboxamido substituted 3-trifluoromethylpyrazoles are obtained with exclusive regioselectivity under transition-metal-free conditions. This decarboxylative [3+2] cycloaddition protocol was enabled by employing trifluoromethyl nitrilimines as 1,3-dipoles, and isoxazolidinediones as CO2-masked alkynyl dipolarophiles. The applicability of this method is further manifested by its compatibility with difluoromethyl, alkyl, aryl, and heteroaryl nitrilimines, as well as the preparation of 4-carboxylic amido analogue of drug Celebrex. (Figure presented.).

Copper-Catalyzed Tandem Dehydrocyanation and [3+2] Cyclo-addition Reactions of Phenacylmalononitriles: Regioselective Synthesis of Functionalized 4-Benzoyl-5-cyanopyrazoles under Mild Conditions

A novel copper-catalyzed [3+2] cycloaddition reaction with concomitant in situ generation of benzoylacrylonitriles and nitrile imines from phenacylmalononitriles and hydrazonoyl chlorides, respectively, is reported. The reaction was performed using copper(I) chloride as catalyst and N-methylimidazole as a clean complexing agent/weak base to afford the functionalized 4-benzoyl-5-cyanopyrazoles in moderate to good yields and excellent regioselectivity under ambient conditions. This method provides rapid access to a wide range of highly functionalized 4-benzoyl-5-cyanopyrazoles.

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.