105519-71-9

Upstream product

• 55135-66-5 9-bromo-9-phenyl-9H-fluorene 
• 130529-58-7 C₆H₁₅NO₂Si*ClH 
• 56-41-7 L-alanin 
• 296774-94-2 (4S)-methyl 2,2-dioxo-3-(9-(9-phenylfluorenyl))-1,2,3-oxathiazolidine-4-carboxylate 

Downstream Products

• 178237-95-1 (4S)-4-methyl-3-N-(9'-phenylfluoren-9'-yl)oxazolidin-5-one 
• 116785-62-7 (2S)-2-[N-(9-phenylfluoren-9-yl)amino]-3-heptanone 
• 178237-96-2 (3S)-3-[N-(9'-phenylfluoren-9'-yl)amino]butan-2-one 
• 178237-99-5 2-methyl-3-[N-(9'-phenylfluoren-9'-yl)amino]butan-2-ol 
• 178237-97-3 (4S)-2,2-dimethyl-4-[N-(9'-phenylfluoren-9'-yl)amino]pentan-3-one 
• 178237-98-4 (2S)-1-phenyl-2-[N-(9'-phenylfluoren-9'-yl)amino]propan-1-one 
• 178238-03-4 (1R,2S)-1-phenyl-2-[N-(9'-phenylfluoren-9'-yl)amino]propan-1-ol 
• 178238-01-2 (1S,2S)-1-phenyl-2-[N-(9'-phenylfluoren-9'-yl)amino]propan-1-ol 
• 105519-83-3 ((S)-2-Benzyloxy-1-methyl-pentyl)-(9-phenyl-9H-fluoren-9-yl)-amine 
• 105519-76-4 methyl (3RS,4S)-3-hydroxy-4-((9-(9-phenylfluorenyl))amino)pentanoate 
• 105519-79-7 ((S)-2-Benzyloxy-1-methyl-ethyl)-(9-phenyl-9H-fluoren-9-yl)-amine 
• 105519-75-3 methyl (4S)-4-((9-(9-phenylfluorenyl))amino)-2-pentenoate 
• 105519-77-5 (2S,3RS)-3-hydroxy-2-((9-(9-phenylfluorenyl))amino)hexane 
• 105519-74-2 (L)-N-(9-phenyl-9-fluorenyl)phenylalanol 

Relevant academic research and scientific papers

Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2

Chemoselective hydrolysis of tert-butyl esters in the presence of other acid-labile groups has been explored by employing α-amino esters and ZnBr2 in DCM. Although N-Boc and N-trityl groups were found to the labile, PhF protected amines were compatible with these Lewis acid deprotection conditions such that a variety of N-(PhF)amino acids were prepared in good yields from their corresponding tert-butyl esters.

Scope and limitations in the use of N-(PhF)serine-derived cyclic sulfamidates for amino acid synthesis

Ring-opening of N-(PhF)serine-derived cyclic sulfamidate 17 was achieved with different nucleophiles (βketo esters, β-keto ketones, dimethyl malonate, nitroethane, sodium azide, imidazole, and potassium thiocyanate) to prepare a variety of amino acid anal

N-trityl and N-phenylfluorenyl carboxyanhydrides of amino acids

Amino acids are derivatized for use in peptide synthesis by conversion to N-carboxyanhydrides that are N-proected by either a trityl or a phenylfluorenyl group.

Configurational Stability of N-Protected α-Amino Aldehydes

A three-step synthesis of N-(9-(9-phenylfluorenyl)-L-alaninal (5) from alanine is described.Exposure to silica or nonnucleophilic base causes no detectable racemization of this α-amino aldehyde.The 9-(9-phenylfluorenyl) N-protecting group also maintains t