116785-62-7Relevant academic research and scientific papers
Enantiospecific Synthesis of N-9-Phenylfluoren-9-yl-α-amino Ketones
Paleo, M. Rita,Calaza, M. Isabel,Sardina, F. Javier
, p. 6862 - 6869 (2007/10/03)
Enantiomerically pure N-(9-phenylfluoren-9-yl)-α-amino ketones were prepared in excellent yields by acylation of organolithium reagents with N-(9-phenylfluoren-9-yl)-α-amino acid-derived oxazolidinones. The method is not applicable for the acylation of Grignard reagents as they attack the methylenic carbon of the oxazolidinone to give the corresponding N-alkylated amino acids 13 in excellent yields. The resulting N-(9-phenylfluoren-9-yl)-α-amino ketones 8 could be stereoselectively reduced to the corresponding syn- or anti-β-amino alcohols depending upon the nature of the reducing agent.
Enantiospecific synthesis of α-amino ketones and β-amino alcohols from the reaction of N-(9-phenylfluoren-9-yl)-alanine oxazolidinone with organolithium reagents
Paleo, M. Rita,Sardina, F. Javier
, p. 3403 - 3406 (2007/10/03)
Enantiomerically pure N-(9-phenylfluoren-9-yl) α-amino ketones were prepared by reaction of the N-Pf-alanine-derived oxazolidinone with organolithium reagents. α-Amino ketones thus obtained could be stereoselectively reduced to the corresponding syn or anti β-amino alcohols depending upon the nature of the reducing agent.
α-Amino Acids as Chiral Educts for Asymmetric Products. Alkylation of N-Phenylfluorenyl α-Amino Ketones. Synthesis of Optically Pure α-Alkyl Carboxylic Acids
Lubell, William D.,Rapoport, Henry
, p. 7447 - 7455 (2007/10/02)
Regioselective enolization and alkylation of N-(9-phenylfluoren-9-yl)amino ketones provides diastereomeric mixtures of α'-alkyl branched α-amino ketones.Separation of the diastereomers provides >99 percent enantiomerically pure α'-alkyl branched α-amino k
