1055263-39-2Relevant academic research and scientific papers
Enantioselective Synthesis of Tropanes: Br?nsted Acid Catalyzed Pseudotransannular Desymmetrization
Carrillo, Luisa,Merino, Pedro,Reyes, Efraim,Rodriguez, Sandra,Tejero, Tomás,Uria, Uxue,Vicario, Jose L.
supporting information, p. 6780 - 6784 (2020/03/19)
The enantioselective synthesis of tropanols has been accomplished through chiral phosphoric acid catalyzed pseudotransannular ring opening of 1-aminocyclohept-4-ene-derived epoxides. The reaction proceeds together with the desymmetrization of the starting
Diastereoselective pyrrolidine synthesis via copper promoted intramolecular aminooxygenation of alkenes: Formal synthesis of (+)-monomorine
Paderes, Monissa C.,Chemler, Sherry R.
supporting information; experimental part, p. 1915 - 1918 (2009/09/25)
The diastereoselectivity of the copper-promoted intramolecular aminooxygenation of various alkene substrates was investigated. a-Substituted 4-pentenyl sulfonamides favor the formation of 2,5-c/s-pyrrolidines (dr > 20:1) giving excellent yields which range from 76-97% while y-substituted substrates favor the 2,3-trans pyrrolidine adducts with moderate selectivity (ca. 3:1). A substrate whose N-substituent was directly tethered to the a-carbon exclusively yielded the 2,5-trans pyrrolidine. The synthetic utility of the method was demonstrated by a short and efficient formal synthesis of (+)-monomorine.
A two-directional approach to the anatoxin alkaloids: Second synthesis of homoanatoxin and efficient synthesis of anatoxin-a
Roe, Stephen J.,Stockman, Robert A.
supporting information; experimental part, p. 3432 - 3434 (2009/02/05)
Total syntheses of the potent neurotoxins, environmental hazards, and biochemical probes anatoxin-a and homoanatoxin have been achieved from a common intermediate using a combined two-directional synthesis-tandem reaction strategy which includes key advan
