1055310-25-2Relevant academic research and scientific papers
Dendritic chain reaction: Responsive release of hydrogen peroxide upon generation and enzymatic oxidation of methanol
Avital-Shmilovici, Michal,Shabat, Doron
experimental part, p. 3643 - 3647 (2010/07/17)
Signal amplification dramatically increases the sensitivity of diagnostic methods. Recently, we introduced a new technique for signal amplification that uses a distinctive dendritic chain reaction (DCR) to generate exponential evolution of a diagnostic signal. In this report, we demonstrate how the modular design of our DCR probe can be used to improve the detection sensitivity. We synthesized a new probe based on a methyl carbonate linkage, which has superior stability in aqueous media. Triggered release of methanol, which was oxidized by alcohol oxidase present in the solution, produced hydrogen peroxide that used as a reagent in the DCR amplification technique. The new probe exhibited higher sensitivity in detection of hydrogen peroxide than our previously reported probe.
Enzymatic activation of hydrophobic self-immolative dendrimers: The effect of reporters with ionizable functional groups
Avital-Shmilovici, Michal,Shabat, Doron
supporting information; experimental part, p. 3959 - 3962 (2010/02/28)
Self-immolative dendrimers are uniquely structured molecules that release multiple tail units through a chain fragmentation initiated by a single cleavage at the dendrimer's core. Although bioactivation of self-immolative dendritic molecules with only two
The pyridinone-methide elimination
Perry-Feigenbaum, Rotem,Baran, Phil S.,Shabat, Doron
supporting information; experimental part, p. 4825 - 4828 (2010/02/16)
The quinone-methide elimination is a common, efficient methodology used in linkers designed to undergo self-fragmentation. Here, for the first time, we demonstrate this elimination in a pyridine ring system. Under physiological conditions, a compound cons
The azaquinone-methide elimination: Comparison study of 1,6- and 1,4-eliminations under physiological conditions
Erez, Rotem,Shabat, Doron
supporting information; experimental part, p. 2669 - 2672 (2009/02/02)
The azaquinone-methide elimination is a powerful and efficient reaction useful for disassembly of spacers in prodrug systems. We and others have used the spacer-technique to develop dendritic and polymeric self-immolative molecular systems that can disass
