105561-87-3Relevant academic research and scientific papers
β-LACTAM SYNTHESIS: CYCLIZATION VERSUS 1,2-ACYL MIGRATION-CYCLIZATION. THE MECHANISM OF THE 1,2-ACYL MIGRATION-CYCLIZATION
Godfrey, Jollie D.,Mueller, Richard H.,Langen, Derek J. Von
, p. 2793 - 2796 (1986)
The cyclization of hydroxamate 1 unexpectedly afforded two isomeric β-lactams 2 and 3.The mechanism for the formation of 3 has been shown by carbon-13 labeling to involve a novel 1,2-acyl migration-cyclization process.
[3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy] acetic acid and intermediate
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, (2008/06/13)
Pharmaceutically acceptable salts of [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy] acetic acid and a process useful in the preparation of such salts are disclosed herein.
Monosulfactams
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, (2008/06/13)
Antibacterial activity is exhibited by monocyclic β-lactam antibiotics having in the 1-position an --O--SO3 H activating group and in the 3-position an acylamino group of the formula STR1 wherein R3 and R4 are each indepen
