β-LACTAM SYNTHESIS: CYCLIZATION VERSUS 1,2-ACYL MIGRATION-CYCLIZATION. THE MECHANISM OF THE 1,2-ACYL MIGRATION-CYCLIZATION

DOI: 10.1016/S0040-4039(00)84644-4

Source and publish data:

Tetrahedron Letters p. 2793 - 2796 (1986)

Update date:2022-09-26

Topics:

Authors:

Godfrey, Jollie D.

Mueller, Richard H.

Langen, Derek J. Von

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Article abstract of DOI:10.1016/S0040-4039(00)84644-4

The cyclization of hydroxamate 1 unexpectedly afforded two isomeric β-lactams 2 and 3.The mechanism for the formation of 3 has been shown by carbon-13 labeling to involve a novel 1,2-acyl migration-cyclization process.

Full text of DOI:10.1016/S0040-4039(00)84644-4

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