105567-78-0

Basic information

• Product Name: C₃₄H₅₂N₇O₁₇P₃S
• Synonyms: C₃₄H₅₂N₇O₁₇P₃S
• CAS NO: 105567-78-0
• Molecular Weight: 955.811
• Mol File: 105567-78-0.mol

Chemical Properties

• CAS DataBase Reference: C₃₄H₅₂N₇O₁₇P₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₅₂N₇O₁₇P₃S(105567-78-0)
• EPA Substance Registry System: C₃₄H₅₂N₇O₁₇P₃S(105567-78-0)

Safety Data

• Hazardous Substances Data: 105567-78-0(Hazardous Substances Data)

Upstream product

• 15687-27-1 ibuprofen 
• 85-61-0 coenzyme A 

Relevant articles and documents

Enantiodifferentiation of ketoprofen by Japanese firefly luciferase from Luciola lateralis

Recently, we found that firefly luciferase exhibited (R)-enantioselective thioesterification activity toward 2-arylpropanoic acids. In the case of Japanese firefly luciferase from Luciola lateralis (LUC-H), the E-value for ketoprofen was approximately 20. In this study, we used a spectrophotometric method to measure the catalytic activity of LUC-H. Using this method allowed us to judge the reaction efficiency easily. Our results confirmed that LUC-H exhibits enantioselective thioesterification activity toward a series of 2-arylpropanoic acids. The highest activity was observed with ketoprofen. We also observed high enzymatic activity of LUC-H toward long-chain fatty acids. These results were reasonable because LUC-H is homologous with long-chain acyl-CoA synthetase. To obtain further information about the enantiodifferentiation mechanism of the LUC-H catalyzed thioesterification of ketoprofen, we determined the kinetic parameters of the reaction relative to each of its three substrates: ketoprofen, ATP, and coenzyme A (CoASH). We found that whereas the affinities of each compound are not affected by the chirality of ketoprofen, enantiodifferentiation is achieved by a chirality-dependent difference in the kcat parameter.