1055703-96-2

Usage

Uses

Used in Medicinal Chemistry and Drug Development:
(1R,2R)-1,2-bis(2-chlorophenyl)ethane-1,2-diamine is utilized as a key intermediate in the design and synthesis of novel pharmaceuticals. Its unique structure allows for the development of new drugs with potential applications in treating various diseases and conditions.
Used in Agrochemicals:
(1R,2R)-1,2-bis(2-chlorophenyl)ethane-1,2-diamine is also employed as a building block in the creation of new agrochemicals, contributing to the development of more effective and targeted pesticides and other agricultural products.
Used in the Synthesis of Complex Organic Molecules:
(1R,2R)-1,2-bis(2-chlorophenyl)ethane-1,2-diamine serves as a valuable precursor in organic synthesis, enabling the production of complex molecules with diverse applications across various industries.
Used in Biological Target Interactions:
Due to its stereochemistry and aromatic rings, (1R,2R)-1,2-bis(2-chlorophenyl)ethane-1,2-diamine is used in research to explore specific interactions with biological targets, potentially leading to advancements in areas such as drug discovery and molecular biology.

Upstream product

• 91589-24-1 o-Chlor-benzaldehyd-imin 
• 89-98-5 2-chloro-benzaldehyde 

Relevant academic research and scientific papers

Diboron glycol ester as well as preparation method, intermediate and application thereof

The invention discloses diboron glycol ester as well as a preparation method, an intermediate and application thereof. The diboron glycol ester can be used for inducing reductive coupling reaction with imine as a substrate, and the substrate can be obtained by reaction of aldehyde and ammonia and is very easy to obtain and quite low in cost. The product can be separated from a reaction system onlyby acid-base operation without column chromatography purification, and the post-treatment mode is convenient and easy to operate. The yield of the obtained product is high, and protective group operation is not needed. The diboron glycol ester has chirality, the stereoselectivity of the reductive coupling reaction is generally excellent, and 99% ee chiral diamine can be obtained only through simple recrystallization. The diboron glycol ester can be obtained by reacting diol with diboron glycol ester, the diol is convenient to prepare and easy to amplify, the diol can be recycled from a reaction solution through simple acid-base operation, the recovery rate reaches 95%, and the preparation cost is further saved.

Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron

We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method signifies the generality of diboron-enabled [3,3]-sigmatropic rearrangement.