91589-24-1

Upstream product

• 89-97-4 2-CHLOROBENZYLAMINE 
• 873-32-5 2-Chlorobenzonitrile 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 15717-17-6 2-chlorothiobenzamide 
• 873-32-5 2-Chlorobenzonitrile 
• 408530-64-3 2-chlorobenzalchloroimine 
• 1055703-96-2 (1R,2R)-1,2-bis(2-chlorophenyl)ethane-1,2-diamine 
• 23031-78-9 3-aminobenzisothiazole 

Relevant academic research and scientific papers

Biomass chitosan-derived nitrogen-doped carbon modified with iron oxide for the catalytic ammoxidation of aromatic aldehydes to aromatic nitriles

Nitrogen-doped carbon catalysts have attracted increasing research attention due to several advantages for catalytic application. Herein, cost-effective, renewable biomass chitosan was used to prepare a N-doped carbon modified with iron oxide catalyst (Fe2O3@NC) for nitrile synthesis. The iron oxide nanoparticles were uniformly wrapped in the N-doped carbon matrix to prevent their aggregation and leaching. Fe2O3@NC-800, which was subjected to carbonization at 800 °C, exhibited excellent activity, selectivity, and stability in the catalytic ammoxidation of aromatic aldehydes to aromatic nitriles. This study may provide a new method for the fabrication of an efficient and cost-effective catalyst system for synthesizing nitriles.

Benzisothiazole hypoxia-inducible factor 2 agonist compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses a benzisothiazole hypoxia-inducible factor 2 agonist compound or a pharmaceutically acceptable salt thereof, the compound can stimulate the transcriptional activity of a hypoxia-inducible factor 2 and enhance the generation and secretion of erythropoietin so as to promote the generation of erythrocytes; the prepared benzisothiazole hypoxia-inducible factor 2 agonist compound or the pharmaceutically acceptable salt thereof can be combined with a prolyl hydroxylase inhibitor to play a synergistic role in improving the transcriptional activity of HIF-2, and can be used for treating hypoxia-inducible factor 2 related diseases, such as ischemic diseases and the like.

Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron

We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method signifies the generality of diboron-enabled [3,3]-sigmatropic rearrangement.

A practical oxidative conversion of aldehydes into N-chloroaldimines

A novel method for the preparation of N-chloroaldimines from commonly available aromatic aldehydes has been developed. The reaction proceeded effectively by two steps: aldehydes were initially transformed into imines and then chloro-substitution with NaClO2 gave the N-chloroaldimines. This simple protocol allows for the preparation of a variety of aromatic N-chloroaldimines in moderate to excellent yields without the isolation of the imine intermediate. We also found that 3-nitrobenzaldehyde and 4-cyanobenzaldehyde were converted into the related benzonitrile directly under the standard conditions.

Structural characteristics and catalytic performance of nanostructured Mn-doped CeO2 solid solutions towards oxidation of benzylamine by molecular O2

This work reports a thorough investigation of nanosized Mn-doped ceria (Ce0.7Mn0.3O2-δ, CM) as an efficient catalyst for oxidation of benzylamine under solvent-free conditions. These catalysts were prepared by a coprecipitation method followed by calcination at 773 and 1073?K. Effect of Mn doping was examined by a variety of characterization techniques. XRD results confirmed formation of single-phase Ce-O-Mn solid solution, and TEM studies showed nanosized nature of particles. BET surface area of CeO2 was significantly enhanced after Mn incorporation. Raman, XPS and H2-TPR results revealed that Mn cations in ceria lattice increase concentration of structural oxygen vacancies and reducibility of ceria. Among various catalysts, the CM calcined at 773?K exhibited a high conversion (～71%), product selectivity (～99.8%), and excellent stability. The better performance has been proved to be due to synergetic interaction between Ce and Mn ions thereby enhanced surface area, improved reducibility, and increased surface adsorbed oxygen species.

Metal-free, one-pot oxidative conversion of aldehydes to primary thioamides in aqueous media

One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Correlation analysis of reactivity in the oxidation of substituted benzylamines by pyridinium hydrobromide perbromide

The oxidation of benzylamine and twenty-seven ortho-, meta- and para-substituted benzylamines by pyridinium hydrobromide perbromide (PHPB), in dimethylsulphoxide (DMSO), leads to the formation of the corresponding aldimines. The reactions are of first order with respect to both PHPB and the amine. The oxidation of deuterated benzylamine exhibited a substantial kinetic isotope effect (kII/kD = 3.20 at 303 K). An addition of pyridinium bromide does not affect the rate. PHPB itself has been postulated as the reactive oxidizing species. The rates of the oxidation of para- and meta-substituted benzylamines were correlated with Taft's and Swain's field and resonance substituent constants. The oxidation of para-substituted benzylamines showed an excellent correlation with Taft's σI and σRBA values; the meta-compounds correlated best with σI and σR0 values. Rates of the ortho-substituted compounds showed a significant correlation with Charton's triparametric equation. Suitable mechanism has been proposed.

Correlation analysis of reactivity in the oxidation of substituted benzylamines by benzyltrimethylammonium tribromide

The oxidation of benzylamine and twenty-seven ortho-, meta- and para-monosubstituted benzylamines by benzyltrimethylammonium tribromide (BTMAB), in dimethylsulphoxide (DMSO), leads to the formation of corresponding aldimines. The reaction is first order with respect to both BTMAB and the amine. The oxidation of deuterated benzylamine exhibited a substantial kinetic isotope effect. Addition of benzyltrimethylammonium bromide does not affect the rate. Tribromide ion has been postulated as the reactive oxidizing species. The rates of the oxidation of para- and meta-substituted benzylamines showed excellent correlation in terms of both Taft's dual substituent-parameter and Charton's triparametric LDR equations, whereas the ortho-substituted compounds exhibited the best correlation with the Charton's tetraparametric LDRS equation. The oxidation of para-substituted benzylamines is more susceptible to the delocalization effect than is the oxidation of ortho- and meta-substituted compounds, which display a greater dependence on the field effect. The low positive value of the η suggests the presence of an electron-deficient centre in the rate-determining transition state with less charge separation. A suitable mechanism has been proposed.