105576-85-0Relevant academic research and scientific papers
Further studies on the reaction of ethyl benzoylacetate with malononitrile: Synthesis of some novel pyridine and pyridazine derivatives
Abdelrazek, Fathy M,Salah El-Din, Abdellatif M,Mekky, Ahmed E
, p. 6787 - 6791 (2007/10/03)
2-Cyano-5-phenyl-3,5-dioxopentanonitrile undergoes alcoholysis followed by Knoevenagel condensation to afford ethyl 4,4-dicyano-3-phenyl-3-butenoate, a thermo dynamically controlled product, which undergoes cyclization in acid medium to afford 2,6-dihydroxy-4-phenylnicotinonitrile. Some azo derivatives of nicotinonitriles and of 2-aminopyran are described. 5-Arylazo-2-aminopyrans are transformed by acid treatment into pyridazine derivatives, whereas without the arylazo substituent pyridines are obtained.
The reaction of ethyl benzoylacetate with malononitrile: A novel synthesis of some pyridazine, pyridazino[2,3-a]quinazoline and pyrrole derivatives
Abdelrazek, Fathy M,Salah El-Din, Abdellatif M,Mekky, Ahmed E
, p. 1813 - 1817 (2007/10/03)
Ethyl benzoylacetate undergoes Claisen condensation reaction with malononitrile to afford 2-cyano-5-phenyl-3,5-dioxopentanonitrile which could be cyclized into 2-aminopyran and coupled with diazonium salts to afford azo derivatives. These azo derivatives and those of ethyl benzoylacetate could be cyclized into 4-oxo-, 6-oxo- and 6-iminopyridazines and pyridazino[2,3-a]quinazolines, respectively. The 6-iminopyridazines could be transformed into the 6-oxopyridazines. The imino- and oxopyridazines could be transformed into pyrrole derivatives.
