105577-89-7Relevant academic research and scientific papers
Studies on &β-Carbolines: Synthesis of 2-, 3- and 6-Substituted 9H-Pyridoindoles as Tubal Occluding Agents
Agarwal, Shiv K.,Saxena, Anil K.,Jain, Padam C.,Malviya, B.,Chandra, Harish,Anand, Nitya
, p. 757 - 760 (2007/10/02)
2-Substituted quaternary ammonium 9H-pyridoindole derivatives (2-4) have been obtained by the condensation of 9H-pyridoindole (1) with aminoalkyl chloride hydrochlorides. 3- and 6-Bromoacetamido-9H-pyridoindole hydrobromides (8/19) have been synthesized by the reaction of bromoacetyl bromide with corresponding 3-/6-amino-9H-pyridoindoles.The reaction of phenyl isothiocyanate on 9H-pyridoindole-3-carboxylic acid hydrazide (9) leads to the corresponding thiosemicarbazide (10), which on cyclisation with 4percent aq NaOH affords the triazine (11). 11 on reaction with C2H5I and ClCH2COOH affords ethyl mercaptotriazine (12) and carboxymethylmercaptotriazine (13) respectively.The ethylsulphonyltriazine (14) has been prepared by the oxidation of ethyl mercaptotriazine (11) while benzylidene derivative (15) has been obtained by condensation of C6H5CHO with hydrazide (9).Condensation of azide 16 with glycine furnishes 9H-pyridoindole-3-carbonylglycine (17).Compounds 1 and 11 produce 100 percent blockade in fallopian tubes of rhesus monkeys and mice respectively.
