1056017-58-3Relevant academic research and scientific papers
Enantioselective Michael addition of malonates to α,β-unsaturated ketones catalyzed by 1,2-diphenylethanediamine
Wang, Wei,Ye, Ling,Shi, Zhichuan,Zhao, Zhigang,Li, Xuefeng
, p. 41699 - 41704 (2019/01/03)
A general and highly enantioselective Michael addition of malonates to cinnamones and chalcones has been developed. The commercially available 1,2-diphenylethanediamine could be directly utilized as the organocatalyst to furnish the desired adducts in satisfactory yield (61-99%) and moderate to excellent enantiopurity (65 to >99% ee). β-Ketoester was also a competent donor and was employed to construct densely functionalized cyclohexenones via a tandem Michael-aldol condensation process.
Enantioselective organocatalytic Michael addition of malonates to α,/β-unsaturated ketones
Li, Pengfei,Wen, Shigang,Yu, Feng,Liu, Qiaoxia,Li, Wenjun,Wang, Yongcan,Liang, Xinmiao,Ye, Jinxing
supporting information; scheme or table, p. 753 - 756 (2009/08/07)
(Chemical Equation Presented) A novel type of primary amine thiourea organocatalysts derived from 1,2-diaminocyclohexane and 9-amino (9-deoxy) cinchona alkaloid was developed into asymmetric Michael addition of malonates to enones. A series of cyclic and
A general organocatalytic enantioselective malonate addition to α,β-unsaturated enones
Wascholowski, Veit,Knudsen, Kristian Rahbek,Mitchell, Claire E. T.,Ley, Steven V.
experimental part, p. 6155 - 6165 (2009/05/27)
A general enantioselective organocatalytic conjugate addition procedure of a variety of malonates to α,β-unsaturated enone systems is presented. The reaction is efficiently catalysed by the pyrrolidinyl tetrazole catalyst 1. Cyclic, acyclic and aromatic e
