105627-80-3

Basic information

• Product Name: 1-Chloro-5-isoquinolinesulfonic Acid
• Synonyms: 1-Chloro-5-isoquinoline Sulfonic Acid;1-Chloro-5-isoquinolinesulfonic Acid;1-chloroisoquinoline-5-sulfonic acid
• CAS NO: 105627-80-3
• Molecular Formula: C₉H₆ClNO₃S
• Molecular Weight: 243.67
• Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates;Sulfur & Selenium Compounds;Heterocycles, Intermediates, Sulfur & Selenium Compounds
• Mol File: 105627-80-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: >2500C
• Appearance: /
• Density: 1.608g/cm³
• Refractive Index: 1.68
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: 1-Chloro-5-isoquinolinesulfonic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-5-isoquinolinesulfonic Acid(105627-80-3)
• EPA Substance Registry System: 1-Chloro-5-isoquinolinesulfonic Acid(105627-80-3)

Safety Data

• Hazardous Substances Data: 105627-80-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

1-Chloro-5-isoquinolinesulfonic Acid (cas# 105627-80-3) is a compound useful in organic synthesis.

InChI:InChI=1/C9H6ClNO3S/c10-9-7-2-1-3-8(15(12,13)14)6(7)4-5-11-9/h1-5H,(H,12,13,14)

Upstream product

• 19493-44-8 1-chloroisoquinoline 

Downstream Products

• 141519-77-9 1-chloroisoquinoline-5-sulphonyl chloride 
• 105628-70-4 1-(1-chloro-5-isoquinolinesulfonyl)homopiperazine 
• 105627-81-4 1-chloro-5-isoquinolinesulfonyl chloride hydrochloride 

Relevant articles and documents

Isoquinolines as urokinase inhibitors

Compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.

Substituted isoquinolinesulfonyl compounds

An isoquinolinesulfonyl compound represented by the formula (I): STR1 wherein R1 : H, Cl, OH A : unsubstituted or substituted ethylene or alkylene R2, R3 : H, alkyl, jointly forming unsubstituted or substituted ethylene or trimethylene R4 : H, alkyl, amidino or an acid salt thereof. They can be prepared, for example, by converting 1-R1 substituted-5-isoquinolinesulfonic acid to the corresponding sulfonyl chloride and subsequently reacting the chloride with a compound of formula STR2 They can be advantageously utilized as vasodilator, cerebral circulation ameliorator, antihypertensive agent and drugs for prevention and treatment of various circulatory organ diseases.