1-Chloro-5-isoquinolinesulfonic Acid

Base Information

• Chemical Name: 1-Chloro-5-isoquinolinesulfonic Acid
• CAS No.: 105627-80-3
• Molecular Formula: C9H6 Cl N O3 S
• Molecular Weight: 243.671
• Hs Code.: 2933499090
• Mol file: 105627-80-3.mol

Synonyms:1-Chloro-5-isoquinoline Sulfonic Acid;1-Chloro-5-isoquinolinesulfonic Acid

Chemical Property of 1-Chloro-5-isoquinolinesulfonic Acid

Chemical Property:

• Melting Point: >2500C
• Refractive Index: 1.68
• PSA: 75.64000
• Density: 1.608g/cm³
• LogP: 3.21570
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98.5% ^*data from raw suppliers

1-Chloro-5-isoquinolinesulfonicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Chloro-5-isoquinolinesulfonic Acid (cas# 105627-80-3) is a compound useful in organic synthesis.

Technology Process of 1-Chloro-5-isoquinolinesulfonic Acid

There total 2 articles about 1-Chloro-5-isoquinolinesulfonic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloroisoquinoline (19493-44-8) → 1-chloro-5-isoquinolinesulphonic acid (105627-80-3) + 1-chloro-5-sulphamoylisoquinoline

Guidance literature:

With sulfuric acid; In isopropyl alcohol;

Reference yield:

1-chloroisoquinoline (19493-44-8) → 1-chloro-5-isoquinolinesulphonic acid (105627-80-3)

Guidance literature:

In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield: 84.0%

1,4-Diazacycloheptane (505-66-8) + 1-chloro-5-isoquinolinesulphonic acid (105627-80-3) → 1-(1-chloro-5-isoquinolinesulfonyl)homopiperazine (105628-70-4)

Guidance literature:

With thionyl chloride; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

upstream raw materials:

1-chloroisoquinoline

Downstream raw materials:

1-chloro-5-isoquinolinesulfonyl chloride hydrochloride

1-(1-chloro-5-isoquinolinesulfonyl)homopiperazine

1-chloroisoquinoline-5-sulphonyl chloride

Refernces

• 1、 -. "Substituted isoquinolinesulfonyl compounds". . . Retrieved 2008/06/13.